The Emerging Role of Apelin in Cardiovascular Disease and Health

被引：43
|
作者：
Quazi, Robin [2 ]
Palaniswamy, Chandrasekar [1 ]
Frishman, William H. [1 ]
机构：
[1] New York Med Coll, Dept Med, Westchester Med Ctr, Valhalla, NY 10595 USA
[2] Washington Univ, Sch Med, Dept Radiol, Barnes Jewish Hosp,Mallinckrodt Inst Radiol, St Louis, MO 63110 USA
来源：
CARDIOLOGY IN REVIEW | 2009年 / 17卷 / 06期
关键词：
apelin; APJ receptor; renin-angiotensin system; ENDOGENOUS PEPTIDE LIGAND; ORPHAN RECEPTOR APJ; CARDIAC DYSFUNCTION; ENDOTHELIAL-CELLS; HEART-FAILURE; IN-VIVO; PRESSURE-OVERLOAD; ANGIOTENSIN-II; BLOOD-PRESSURE; FOOD-INTAKE;
D O I：
10.1097/CRD.0b013e3181b3fe0d
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This article focuses oil a newly discovered bioactive peptide, termed apelin, as it relates to the cardiovascular system. Apelin, through its G-protein coupled receptor, seems to primarily exert effects in blood pressure control, and may play a role in heart failure and in myocardial reperfusion injury. In addition, at least some of apelin's effects appear to stein from an interaction with the renin-angiotensin system. Apelin may provide a target for drug treatment of cardiovascular disease.
引用
收藏
页码：283 / 286
页数：4
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