Efp as a primary estrogen-responsive gene in human breast cancer

被引：65
|
作者：
Ikeda, K
Orimo, A
Higashi, Y
Muramatsu, M
Inoue, S
机构：
[1] Saitama Med Sch, Dept Biochem, Moroyama, Saitama 3500495, Japan
[2] Saitama Canc Ctr, Ina, Saitama 3620806, Japan
[3] Japan Sci & Technol Corp, CREST, Saitama, Japan
来源：
FEBS LETTERS | 2000年 / 472卷 / 01期
关键词：
estrogen; estrogen receptor; breast cancer; estrogen-responsive element; transcriptional regulation;
D O I：
10.1016/S0014-5793(00)01421-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have previously isolated the efp (estrogen-responsive finger protein) that is required for the normal estrogen-induced cell proliferation. Here, we show the genomic organization of the human efp gene which consists of nine exons, The efp mRNA was expressed in human breast tumors and the estrogen-induced expression of the efp was found in MCF-7 human breast cancer cells, Moreover, efp promoter activity was enhanced through the estrogen-responsive element dependent on estrogen and estrogen receptor. These results suggest that the efp can mediate estrogen actions such as cell growth in human breast cancer as a primary responsive gene. (C) 2000 Federation of European Biochemical Societies.
引用
收藏
页码：9 / 13
页数：5
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