A comparison of oleamide in the brains of hibernating and non-hibernating Richardson's ground squirrel (Spermophilus richardsonii) and its inability to bind to brain fatty acid binding protein

被引：10

作者：

Stewart, JM

Boudreau, NM

Blakely, JA

Storey, KB

机构：

[1] Mt Allison Univ, Dept Biol, Biochem Programme, Sackville, NB E4L 1G7, Canada

[2] Carleton Univ, Inst Biochem, Dept Biol, Ottawa, ON K1S 5B6, Canada

来源：

JOURNAL OF THERMAL BIOLOGY | 2002年 / 27卷 / 04期

基金：

加拿大自然科学与工程研究理事会;

关键词：

oleamide; hibernation; sleep deprivation; brain fatty acid-binding protein; Richardson's ground squirrel;

D O I：

10.1016/S0306-4565(01)00093-6

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hibernation has been suggested to cause sleep debt, and since oleamide is elevated in the central nervous system of sleep-deprived mammals we hypothesized that brains from hibernating mammals would contain more oleamide than those that were not hibernating. Oleamide was 2.6-fold greater in brains of hibernating Richardson's ground squirrel (Spermophilus richardsonii) than in euthermic brains. Additionally. brain fatty acid-binding protein did not bind oleamide and does not represent a solubilized pool of oleamide. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：309 / 315

页数：7