A Mouse Model Carrying The R502W Mutation In Cardiac Myosin Binding Protein C (cMyBP-C) Leads To Hypertrophic Myocardial Remodeling In The Absence Of <cMyBP-C> Haploinsufficiency

被引：0
|
作者：
Sen-Martin, Laura
Fernandez-Trasancos, Angel
Lopez-Unzu, Miguel
Sanchez-Ortiz, David
Pricolo, Maria Rosaria
Alegre-Cebollada, Jorge
机构：
来源：
CIRCULATION RESEARCH | 2022年 / 131卷
关键词：
Myocardium; Cardiovascular disease; Hypertrophic cardiomyopathy;
D O I：
10.1161/res.131.suppl_1.EC105
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
EC105
引用
收藏
页数：2
相关论文
共 32 条
  • [1] Cardiac myosin binding protein C (cMyBP-C) enhances stability of contractile filaments
    Kulikovskaya, I
    McClellan, G
    Winegrad, S
    BIOPHYSICAL JOURNAL, 2004, 86 (01) : 211A - 211A
  • [2] Cardiac-specific overexpression of PKCε increases phosphorylation of the cardiac myosin binding protein C (cMyBP-C)
    Zhao, Q
    Goldspink, P
    Walker, L
    Xiao, L
    Buttrick, P
    JOURNAL OF CARDIAC FAILURE, 2005, 11 (06) : S108 - S108
  • [3] Expression of cardiac myosin-binding protein-C (cMyBP-C) in Drosophila as a model for the study of human cardiomyopathies
    Manh, TPV
    Mokrane, M
    Flavigny, J
    Carrier, L
    Sémériva, M
    Piovant, M
    Röder, L
    HUMAN MOLECULAR GENETICS, 2005, 14 (01) : 7 - 17
  • [4] Cardiac Myosin Binding-Protein C (cMyBP-C) Phosphorylation affect Cross-Bridge Function
    Wang, Li
    Ji, Xiang
    Sadayappan, Sakthivel
    Kawai, Masakata
    BIOPHYSICAL JOURNAL, 2013, 104 (02) : 158A - 158A
  • [5] Loaded sarcomere shortening in permeabilized cardiac myocytes: Role of cardiac myosin binding protein-C (cMyBP-C)
    McDonald, Kerry S.
    Kalogeris, Theodore J.
    Veteto, Adam B.
    Davis, Daniel J.
    Hanft, Laurin M.
    BIOPHYSICAL JOURNAL, 2024, 123 (03) : 124A - 124A
  • [6] Mechanical Stability of the Cardiac Myosin Binding Protein-C (CMybP-C) Motif is Phosphorylation-Dependent
    Michalek, Arthur J.
    Gulick, James
    Robbins, Jeffrey
    Warshaw, David M.
    BIOPHYSICAL JOURNAL, 2012, 102 (03) : 436A - 436A
  • [7] PKC∈ increases phosphorylation of cardiac myosin binding protein C (cMyBP-C) at Serine302 in vivo
    Zhao, D
    Goldspink, PH
    Du, YM
    Walker, LA
    Xiao, L
    Buttrick, PM
    CIRCULATION, 2005, 112 (17) : U356 - U356
  • [8] Chronic mavacamten treatment prevents development of contractile dysfunction in cMyBP-C null engineered heart tissue constructs, but not in constructs carrying the cMyBP-C W792R missense mutation
    De Lange, Willem
    Gauchan, Angeela
    Farrell, Emily
    Ralphe, J. Carter
    CIRCULATION RESEARCH, 2024, 135
  • [9] Crystallization by Controlled Evaporation Leading to High Resolution Crystals of the C1 Domain of Cardiac Myosin Binding Protein-C (cMyBP-C)
    Govada, Lata
    Chayen, Naomi E.
    CRYSTAL GROWTH & DESIGN, 2009, 9 (04) : 1729 - 1732
  • [10] Cardiac myosin binding protein-C (cMyBP-C) directly modulates actomyosin binding and kinetics independent of LMM and S2 binding
    Saber, Walid
    Begin, Kelly J.
    Warshaw, David M.
    VanBuren, Peter
    CIRCULATION, 2007, 116 (16) : 301 - 302
1234