Weight Loss in Obese Leptin-Resistant Rats Induced by Activation of CRH Neurons in the Paraventricular Nucleus of the Hypothalamus by Overexpression of Substantial Nigral-Injected rAAV5-GDNF

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作者
Manfredsson, F. P. [1 ]
Tumer, N. [2 ,3 ]
Erdos, B. [2 ,3 ]
Landa, T. [2 ,3 ]
Broxson, C. S. [2 ,3 ]
Sullivan, L. F. [1 ]
Rising, A. C. [1 ]
Foust, K. D. [1 ]
Zhang, Y. [2 ,3 ]
Muzyczka, N. [4 ]
Gorbatyuk, O. S. [4 ]
Scarpace, P. J. [2 ,3 ]
Mandel, R. J. [1 ]
机构
[1] Univ Florida, Coll Med, Dept Neurosci, Powell Gene Therapy Ctr,McKnight Brain Inst, Gainesville, FL 32610 USA
[2] Dept Vet Affairs Med Ctr, Ctr Geriatr Res Educ & Clin, Gainesville, FL USA
[3] Univ Florida, Coll Med, Dept Pharmacol & Therapeut, Gainesville, FL 32610 USA
[4] Univ Florida, Coll Med, Powell Gene Therapy Ctr, Dept Mol Genet & Microbiol, Gainesville, FL USA
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Q813 [细胞工程];
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页码:225 / 225
页数:1
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  • [1] Bilateral Nigral rAAV5-Mediated GDNF Over-Expression Activates CRH Neurons in the Paraventricular Nucleus of the Hypothalamus and Induces Robust Weight Loss in Obese Leptin-Resistant Rats
    Manfredsson, Fredric P.
    Tumer, Nihal
    Edros, Benedek
    Landa, Tessa
    Broxson, Chritopher S.
    Sullivan, Layla F.
    Rising, Aaron C.
    Foust, Kevin D.
    Zhang, Yi
    Muzyczka, Nicholas
    Gorbatuk, Oleg S.
    Scarpace, Philip J.
    Mandel, Ronald J.
    [J]. MOLECULAR THERAPY, 2009, 17 : S73 - S73