Linoleic acid, glycemic control and Type 2 diabetes

被引:54
|
作者
Belury, Martha A. [1 ]
Cole, Rachel M. [2 ]
Snoke, Deena B. [2 ]
Banh, Taylor [2 ]
Angelotti, Austin [2 ]
机构
[1] Ohio State Univ, Program Human Nutr, 1787 Neil Ave,302 Campbell Hall, Columbus, OH 43210 USA
[2] Ohio State Univ, Grad Sch, OSU Nutr Grad Program, Columbus, OH 43210 USA
关键词
Adiponectin; Insulin resistance; Linoleic acid; Monounsaturated fat; Polyunsaturated fat; Saturated fat; FATTY-ACID; DIETARY-FAT; INSULIN SENSITIVITY; METABOLIC SYNDROME; SATURATED FAT; RISK; WOMEN; INFLAMMATION; ASSOCIATION; DISEASE;
D O I
10.1016/j.plefa.2018.03.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Dietary fat quality, especially the intake of specific types of fatty acids, impacts the risk of many chronic diseases, including cardiovascular diseases, certain cancers and type 2 diabetes (T2DM). A recent pooled analysis involving 20 studies from around the world revealed that higher linoleic acid (18:2n-6 LA) biomarker is associated with dose-dependent decreases in the incidence of T2DM. This latest study corroborates earlier cross-sectional studies and intervention trials showing that biomarkers of LA intake are associated with reduced risk of T2DM and better glycemic control and/or insulin sensitivity. This review highlights key clinical trials that have evaluated the role of LA in glycemia and the related condition, insulin sensitivity.
引用
收藏
页码:30 / 33
页数:4
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