Direct synthesis of α-ketothioamides from aryl methyl ketones and amines via I2-promoted sp3 C-H functionalization

被引：47
|
作者：
Li, Hong-Zheng [1 ]
Xue, Wei-Jian [1 ]
Wu, An-Xin [1 ]
机构：
[1] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China
来源：
TETRAHEDRON | 2014年 / 70卷 / 31期
基金：
中国国家自然科学基金;
关键词：
Domino reaction; sp(3) C-H functionalization; alpha-Ketothioamides; WILLGERODT-KINDLER REACTION; ONE-POT SYNTHESIS; METAL-FREE; PHOSPHORUS PENTASULFIDE; EFFICIENT SYNTHESIS; KINETIC RESOLUTION; MOLECULAR-IODINE; ALDOL REACTION; BOND FORMATION; THIOAMIDES;
D O I：
10.1016/j.tet.2014.05.045
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A domino reaction that involves the formation of C=S and C-N bonds in one process via sp(3) C-H functionalization strategy has been developed. This reaction affords an efficient and direct method for the synthesis of alpha-ketothioamides from aryl methyl ketones, amines, and sodium hydrosulfide under the promotion of iodine. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4645 / 4651
页数：7
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