ABO blood type incompatibility lost the unfavorable impact on outcome in unrelated bone marrow transplantation

被引：13

作者：

Kimura, Fumihiko ^{[1
]}

Kanda, Junya ^{[2
]}

Ishiyama, Ken ^{[3
]}

Yabe, Toshio ^{[4
]}

Yoshifuji, Kota ^{[5
]}

Fukuda, Takahiro ^{[6
]}

Ozawa, Yukiyasu ^{[7
]}

Iwato, Koji ^{[8
,9
]}

Eto, Tetsuya ^{[10
]}

Mori, Takehiko ^{[11
]}

Uchida, Naoyuki ^{[12
]}

Ota, Shuichi ^{[13
]}

Sakura, Toru ^{[14
]}

Ichinohe, Tatsuo ^{[15
]}

Atsuta, Yoshiko ^{[16
,17
]}

Kanda, Yoshinobu ^{[18
]}

机构：

[1] Natl Def Med Coll, Div Hematol, Tokorozawa, Saitama, Japan

[2] Kyoto Univ, Grad Sch Med, Dept Hematol & Oncol, Kyoto, Japan

[3] Kanazawa Univ Hosp, Dept Hematol & Oncol, Kanazawa, Ishikawa, Japan

[4] Japanese Red Cross Kanto Koshinetsu Block Blood C, Tokyo, Japan

[5] Komagome Hosp, Tokyo Metropolitan Canc & Infect Dis Ctr, Hematol Div, Tokyo, Japan

[6] Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan

[7] Japanese Red Cross Nagoya First Hosp, Dept Hematol, Nagoya, Aichi, Japan

[8] Hiroshima Red Cross Hosp, Dept Hematol, Hiroshima, Japan

[9] Atom Bomb Survivors Hosp, Hiroshima, Japan

[10] Hamanomachi Hosp, Dept Hematol, Fukuoka, Fukuoka, Japan

[11] Keio Univ, Dept Med, Div Hematol, Sch Med, Tokyo, Japan

[12] Federat Natl Publ Serv Personnel Mutual Aid Assoc, Dept Hematol, Tokyo, Japan

[13] Hokkaido Univ, Dept Gastroenterol & Hematol, Grad Sch Med, Sapporo, Hokkaido, Japan

[14] Saiseikai Maebashi Hosp, Div Hematol, Maebashi, Gunma, Japan

[15] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Hematol & Oncol, Hiroshima, Japan

[16] Japanese Data Ctr Hematopoiet Cell Transplantat, Nagoya, Aichi, Japan

[17] Nagoya Univ, Dept Healthcare Adm, Grad Sch Med, Nagoya, Aichi, Japan

[18] Jichi Med Univ, Saitama Med Ctr, Div Hematol, Saitama, Japan

来源：

BONE MARROW TRANSPLANTATION | 2019年 / 54卷 / 10期

关键词：

ALLELE MISMATCH COMBINATIONS; STEM-CELL TRANSPLANTATION; VERSUS-HOST-DISEASE; TRUMP DATA; DONOR; JAPAN; REGARDLESS; SCRIPTS;

D O I：

10.1038/s41409-019-0496-2

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The effects of ABO incompatibility on hematopoietic stem cell transplantation remain controversial. Large cohorts are required to obtain findings that allow for definite conclusions. We previously demonstrated poor overall survival and increased treatment-related mortality (TRM) in ABO-incompatible unrelated bone marrow transplantation (UR-BMT) performed during the period from 1993 to 2005. To improve our understanding of ABO-incompatible transplantation, we reanalyzed the effects of ABO mismatch in a UR-BMT cohort in Japan after 2000. Multivariate analyses for the 2000-2006 cohort showed that major ABO mismatch was associated with poor overall survival (HR, 1.211; 95% CI, 1.062 to 1.381; p = 0.004) and increased TRM (HR, 1.357; 95% CI, 1.146 to 1.608; p < 0.001). In the 2007-2015 cohort, major incompatibility had no effect on overall survival (HR, 0.987, p = 0.804) or TRM (HR, 1.020, p = 0.790). Delayed engraftment of erythrocytes, platelets, and neutrophils in cases of major mismatch was common between the two cohorts. In conclusion, the adverse effect of ABO major incompatibility has become less significant over time.

引用

页码：1676 / 1685

页数：10

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