A systematic review of non-pharmacological interventions to improve therapeutic adherence in tuberculosis

Background: Reviews examining non-pharmacological interventions to improve therapeutic adherence in tuberculosis have several limitations (design, quality assessment ...). Consequently, for clinical practice, it is important to generate a review containing all the information to improve patient adherence, solving the previous issues. Objectives: To examine non-pharmacological interventions to improve therapeutic adherence in tuberculosis through clinical trials. Methods: A systematic review in MEDLINE/EMBASE was performed. Results: Thirty seven papers were analysed. The disease treatment interventions were disparate, grouped into: education, psychological interventions, new technologies, directly observed treatment, incentives and improved access to health services. In the treatment of latent infection, the majority of studies were conducted in the marginal population (drug addicts, homeless individuals and prisoners) and were based mainly on the provision of incentives. Study quality was generally low. Conclusions: Great variability exists in the studies comparing strategies for identifying interventions, objectives and effects. The designs carried out generally have methodological deficits. (C) 2019 Elsevier Inc. All rights reserved.