Transition-Metal-Free Synthesis of Indolizines from Electron-Deficient Alkenes via One-Pot Reaction Using TEMPO as an Oxidant

被引：38
|
作者：
Shi, Fei [1 ,2 ]
Zhang, Yu [1 ,2 ]
Lu, Zhaole [2 ]
Zhu, Xiaolei [2 ]
Kan, Weiqiu [2 ]
Wang, Xiang [2 ]
Hu, Huayou [1 ,2 ]
机构：
[1] Ningxia Univ, Sch Chem & Chem Engn, Yinchuan 750021, Peoples R China
[2] Huaiyin Normal Univ, Sch Chem & Chem Engn, Jiangsu Key Lab Chem Low Dimens Mat, Huaian 223300, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2016年 / 48卷 / 03期
关键词：
N-ylide; alkenes; 1,3-dipolar cycloaddition; tandem reaction; dehydrogenation; AEROBIC OXIDATION; MOLECULAR-OXYGEN; CARBON-CARBON; BOND-CLEAVAGE; C-C; DERIVATIVES; ALCOHOLS; FLUORESCENCE; INHIBITORS; EQUIVALENT;
D O I：
10.1055/s-0035-1560973
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot method for the synthesis of multisubstituted indolizines from alpha-halo carbonyl compounds, pyridines, and electron-deficient alkenes is reported. The oxidative dehydrogenation reaction takes place under transition-metal-free conditions using TEMPO as an oxidant. This protocol uses ready available starting materials in a convenient procedure under mild reaction conditions.
引用
收藏
页码：413 / 420
页数：8
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