AllergoOncology: Microbiota in allergy and cancer-A European Academy for Allergy and Clinical Immunology position paper

被引：21

作者：

Untersmayr, Eva ^{[1
]}

Bax, Heather J. ^{[2
,3
]}

Bergmann, Christoph ^{[4
]}

Bianchini, Rodolfo ^{[5
]}

Cozen, Wendy ^{[6
,7
,8
]}

Gould, Hannah J. ^{[9
,10
,11
]}

Hartmann, Karin ^{[12
]}

Josephs, Debra H. ^{[2
,3
]}

Levi-Schaffer, Francesca ^{[13
]}

Penichet, Manuel L. ^{[14
,15
,16
,17
,18
]}

O'Mahony, Liam ^{[19
,20
]}

Poli, Aurelie ^{[21
]}

Redegeld, Frank A. ^{[22
]}

Roth-Walter, Franziska ^{[5
]}

Turner, Michelle C. ^{[23
,24
,25
,26
]}

Vangelista, Luca ^{[27
]}

Karagiannis, Sophia N. ^{[2
]}

Jensen-Jarolim, Erika ^{[1
,5
]}

机构：

[1] Med Univ Vienna, Ctr Pathophysiol Infectiol & Immunol, Inst Pathophysiol & Allergy Res, Vienna, Austria

[2] Kings Coll London, Guys Hosp, Sch Basic & Med Biosci, St Johns Inst Dermatol, London, England

[3] Kings Coll London, Guys Hosp, Sch Canc & Pharmaceut Sci, London, England

[4] ENT Res Inst Clin Studies, Essen, Germany

[5] Univ Vienna, Med Univ Vienna, Univ Vet Med Vienna, Comparat Med,Interuniv Messerli Res Inst, Vienna, Austria

[6] Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Ctr Genet Epidemiol, Los Angeles, CA USA

[7] Univ Southern Calif, Keck Sch Med, Dept Pathol, Los Angeles, CA USA

[8] Keck Sch Med Los Angeles, Norris Comprehens Canc Ctr, Los Angeles, CA USA

[9] Kings Coll London, Sch Basic & Med Biosci, Randall Ctr Cell & Mol Biophys, New Hunts House, London, England

[10] MRC, London, England

[11] Asthma UK Ctr Allerg Mech Asthma, London, England

[12] Univ Lubeck, Dept Dermatol, Lubeck, Germany

[13] Hebrew Univ Jerusalem, Inst Drug Res, Fac Med, Pharmacol & Expt Therapeut Unit,Sch Pharm, Jerusalem, Israel

[14] Univ Calif Los Angeles, David Geffen Sch Med, Dept Surg, Div Surg Oncol, Los Angeles, CA 90095 USA

[15] Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

[16] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA

[17] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90024 USA

[18] Univ Calif Los Angeles, AIDS Inst, Los Angeles, CA USA

[19] Natl Univ Ireland, APC Microbiome Ireland, Dept Med, Cork, Ireland

[20] Natl Univ Ireland, APC Microbiome Ireland, Dept Microbiol, Cork, Ireland

[21] Luxembourg Inst Hlth, Dept Infect & Immun, Esch Sur Alzette, Luxembourg

[22] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Fac Sci, Div Pharmacol, Utrecht, Netherlands

[23] Barcelona Inst Global Hlth ISGlobal, Barcelona, Spain

[24] UPF, Barcelona, Spain

[25] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain

[26] Univ Ottawa, McLaughlin Ctr Populat Hlth Risk Assessment, Ottawa, ON, Canada

[27] Nazarbayev Univ, Dept Biomed Sci, Sch Med, Astana, Kazakhstan

来源：

ALLERGY | 2019年 / 74卷 / 06期

基金：

奥地利科学基金会; 美国国家卫生研究院; 英国医学研究理事会; 以色列科学基金会;

关键词：

allergy; cancer; hygiene hypothesis; microbiota; oncoimmunology; VITAMIN-D SUPPLEMENTATION; CHAIN FATTY-ACIDS; GUT MICROBIOTA; FOOD ALLERGY; MAST-CELLS; SUBLINGUAL IMMUNOTHERAPY; INFLAMMATORY RESPONSES; ATOPIC-DERMATITIS; ORAL MICROBIOME; DIETARY FIBER;

D O I：

10.1111/all.13718

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The microbiota can play important roles in the development of human immunity and the establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and exposure to viruses or bacteria, and medical interventions with antibiotics or anti-ulcer medications, regulate phylogenetic variability and the quality of cross talk between innate and adaptive immune cells via mucosal and skin epithelia. More recently, microbiota and their composition have been linked to protective effects for health. Imbalance, however, has been linked to immune-related diseases such as allergy and cancer, characterized by impaired, or exaggerated immune tolerance, respectively. In this AllergoOncology position paper, we focus on the increasing evidence defining the microbiota composition as a key determinant of immunity and immune tolerance, linked to the risk for the development of allergic and malignant diseases. We discuss novel insights into the role of microbiota in disease and patient responses to treatments in cancer and in allergy. These may highlight opportunities to improve patient outcomes with medical interventions supported through a restored microbiome.

引用

页码：1037 / 1051

页数：15

共 50 条

[1] AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer-a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)
Ferastraoaru, D.
Bax, H. J.
Bergmann, C.
Capron, M.
Castells, M.
Dombrowicz, D.
Fiebiger, E.
Gould, H. J.
Hartmann, K.
Jappe, U.
Jordakieva, G.
Josephs, D. H.
Levi-Schaffer, F.
Mahler, V
Poli, A.
Rosenstreich, D.
Roth-Walter, F.
Shamji, M.
Steveling-Klein, E. H.
Turner, M. C.
Untersmayr, E.
Karagiannis, S. N.
Jensen-Jarolim, E.
[J]. CLINICAL AND TRANSLATIONAL ALLERGY, 2020, 10 (01)
[2] AllergoOncology: Danger signals in allergology and oncology: A European Academy of Allergy and Clinical Immunology (EAACI) Position Paper
Bergmann, Christoph
Poli, Aurelie
Agache, Ioana
Bianchini, Rodolfo
Bax, Heather J.
Castells, Mariana
Crescioli, Silvia
Dombrowicz, David
Ferastraoaru, Denisa
Fiebiger, Edda
Gould, Hannah J.
Hartmann, Karin
Izquierdo, Elena
Jordakieva, Galateja
Josephs, Debra H.
Jutel, Marek
Levi-Schaffer, Francesca
de las Vecillas, Leticia
Lotze, Michael T.
Osborn, Gabriel
Pascal, Mariona
Redegeld, Frank
Rosenstreich, David
Roth-Walter, Franziska
Schmidt-Weber, Carsten
Shamji, Mohamed
Steveling, Esther H.
Turner, Michelle C.
Untersmayr, Eva
Jensen-Jarolim, Erika
Karagiannis, Sophia N.
[J]. ALLERGY, 2022, 77 (09) : 2594 - 2617
[3] Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology
Roberts, G.
Xatzipsalti, M.
Borrego, L. M.
Custovic, A.
Halken, S.
Hellings, P. W.
Papadopoulos, N. G.
Rotiroti, G.
Scadding, G.
Timmermans, F.
Valovirta, E.
[J]. ALLERGY, 2013, 68 (09) : 1102 - 1116
[4] Non-allergic rhinitis: Position paper of the European Academy of Allergy and Clinical Immunology
Hellings, P. W.
Klimek, L.
Cingi, C.
Agache, I.
Akdis, C.
Bachert, C.
Bousquet, J.
Demoly, P.
Gevaert, P.
Hox, V.
Hupin, C.
Kalogjera, L.
Manole, F.
Moesges, R.
Mullol, J.
Muluk, N. B.
Muraro, A.
Papadopoulos, N.
Pawankar, R.
Rondon, C.
Rundenko, M.
Seys, S. F.
Toskala, E.
Van Gerven, L.
Zhang, L.
Zhang, N.
Fokkens, W. J.
[J]. ALLERGY, 2017, 72 (11) : 1657 - 1665
[5] FOOD ALLERGY - POSITION PAPER FROM THE EUROPEAN-ACADEMY-OF-ALLERGOLOGY-AND-CLINICAL-IMMUNOLOGY
WUTHRICH, B
[J]. HAUTARZT, 1995, 46 (02): : 73 - 75
[6] European Academy of Allergy and Clinical Immunology position paper on endoscopic scoring of nasal polyposis
Gevaert, Philippe
De Craemer, Jarno
Bachert, Claus
Blauwblomme, Manon
Chaker, Adam
Cingi, Cemal
Hellings, Peter W.
Hopkins, Claire
Hox, Valerie
Fokkens, Wytske J.
Klimek, Ludger
Lund, Valerie
Moesges, Ralph
Mullol, Joaquim
Pfaar, Oliver
Scadding, Glenis
Tomazic, Peter Valentin
Van Zele, Thibaut
Vlaminck, Stephan
Wagenmann, Martin
Toppila-Salmi, Sanna
Alobid, Isam
[J]. ALLERGY, 2023, 78 (04) : 912 - 922
[7] Allergy and pediatric allergy and immunology are the official organs of the European academy of allergology and clinical immunology
Warner, JO
Bousquet, J
[J]. PEDIATRIC ALLERGY AND IMMUNOLOGY, 2004, 15 (06) : 479 - 484
[8] Allergy and pediatric allergy and immunology are the official organs of the european academy of allergology and clinical immunology
Bousquet, J
Warner, JO
[J]. ALLERGY, 2004, 59 (12) : 1333 - 1338
[9] Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report
Burks, A. W.
Calderon, M. A.
Casale, T.
Cox, L.
Demoly, P.
Jutel, M.
Nelson, H.
Akdis, C. A.
[J]. REVUE FRANCAISE D ALLERGOLOGIE, 2014, 54 (02): : 66 - 77
[10] Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report
Burks, A. Wesley
Calderon, Moises A.
Casale, Thomas
Cox, Linda
Demoly, Pascal
Jutel, Marek
Nelson, Harold
Akdis, Cezmi A.
[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2013, 131 (05) : 1288 - U65

← 1 2 3 4 5 →