Impaired CD4+ T cell recognition of SARS-CoV-2 variants of concern

被引：3
|
作者：
Taylor, Graham S. [1 ]
Long, Heather M. [1 ]
机构：
[1] Univ Birmingham, Birmingham, England
来源：
NATURE IMMUNOLOGY | 2022年 / 23卷 / 12期
关键词：
D O I：
10.1038/s41590-022-01353-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We isolated CD4(+) T cell clones from healthcare workers infected with SARS-CoV-2 during the first COVID-19 wave and identified 21 epitopes across three viral proteins: spike, membrane and nucleoprotein. Focusing on spike protein, for seven of ten epitopes mutated in variants of concern, we found that T cell recognition was impaired.
引用
收藏
页码：1671 / 1672
页数：2
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