Synthesis and structure-activity relationships of γ-carboline derivatives as potent and selective cysLT1 antagonists

被引：16
|
作者：
Bonjoch, Josep [3 ]
Diaba, Faiza [3 ]
Pages, Lluis [2 ]
Perez, Daniel [1 ]
Soca, Lidia [1 ]
Miralpeix, Montserrat [2 ]
Vilella, Dolors [2 ]
Anton, Paquita [2 ]
Puig, Carles [1 ]
机构：
[1] Almirall SA, Med Chem, Barcelona 08960, Spain
[2] Almirall SA, Res Ctr, Barcelona 08980, Spain
[3] Univ Barcelona, Lab Quim Organ, Fac Farm, Inst Biomed IBUB, E-08028 Barcelona, Spain
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 15期
关键词：
Cys-LT1; antagonists; gamma-Carboline; Carboxylic derivatives; Anti-inflammatory compounds; ANTIALLERGIC ACTIVITY; AMPHOTERIC DRUGS; GUINEA-PIG;
D O I：
10.1016/j.bmcl.2009.05.094
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A gamma-carboline series of cysLT(1) receptor antagonists has been prepared. Some of the compounds show good potencies both, in vitro and in vivo, compared to the standard compounds. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4299 / 4302
页数：4
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