Antibody-mediated xenograft injury: Mechanisms and protective strategies

被引：44
|
作者：
Pierson, Richard N., III [1 ,2 ]
机构：
[1] Univ Maryland, Surg Care Clin Ctr, Sch Med, VA Maryland Hlth Care Syst,Dept Surg, Baltimore, MD 21201 USA
[2] Baltimore VAMC, Baltimore, MD 21201 USA
来源：
TRANSPLANT IMMUNOLOGY | 2009年 / 21卷 / 02期
关键词：
Xenograft injury; Clinical transplantation; Hyperacute rejection; Complement; Coagulation; Antibody; HYPERACUTE LUNG REJECTION; BABOON CARDIAC TRANSPLANTS; ACUTE VASCULAR REJECTION; GENE-KNOCKOUT PIGS; NATURAL ANTIBODIES; TRANSGENIC PIGS; IN-VIVO; HEART-TRANSPLANTATION; ENDOTHELIAL-CELLS; NONHUMAN-PRIMATES;
D O I：
10.1016/j.trim.2009.03.008
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The use of porcine organs for clinical transplantation is a promising potential solution to the shortage of human organs. Preformed anti-pig antibody is the primary cause of hyperacute rejection, while elicited antibody can contribute to subsequent "delayed" xenograft rejection. This article will review recent progress to overcome antibody mediated xenograft rejection, through modification of the host immunity and use of genetically engineered pig organs. Published by Elsevier B.V.
引用
收藏
页码：65 / 69
页数：5
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