Tissue Engineering and Regenerative Repair in Wound Healing

被引：133

作者：

Hu, Michael S. ^{[1
,2
]}

Maan, Zeshaan N. ^{[1
]}

Wu, Jen-Chieh ^{[1
]}

Rennert, Robert C. ^{[1
]}

Hong, Wan Xing ^{[1
]}

Lai, Tiffany S. ^{[3
]}

Cheung, Alexander T. M. ^{[1
]}

Walmsley, Graham G. ^{[1
]}

Chung, Michael T. ^{[1
]}

McArdle, Adrian ^{[1
]}

Longaker, Michael T. ^{[1
]}

Lorenz, H. Peter ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Hagey Lab Pediat Regenerat Med, Dept Surg,Div Plast Surg, Stanford, CA 94305 USA

[2] Univ Hawaii, John A Burns Sch Med, Dept Surg, Honolulu, HI 96822 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Obstet & Gynecol, Los Angeles, CA 90095 USA

来源：

ANNALS OF BIOMEDICAL ENGINEERING | 2014年 / 42卷 / 07期

关键词：

Biomaterials; Cell-based therapeutics; Fetal wound healing; Stem cells; MESENCHYMAL STEM-CELLS; ACELLULAR DERMAL MATRIX; FREE-FORM FABRICATION; FACTOR-BETA MODULATOR; DIFFERENTIAL EXPRESSION; HYALURONIC-ACID; SCAR FORMATION; STROMAL CELLS; GROWTH-FACTOR; TRANSFORMING GROWTH-FACTOR-BETA-1;

D O I：

10.1007/s10439-014-1010-z

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Wound healing is a highly evolved defense mechanism against infection and further injury. It is a complex process involving multiple cell types and biological pathways. Mammalian adult cutaneous wound healing is mediated by a fibroproliferative response leading to scar formation. In contrast, early to mid-gestational fetal cutaneous wound healing is more akin to regeneration and occurs without scar formation. This early observation has led to extensive research seeking to unlock the mechanism underlying fetal scarless regenerative repair. Building upon recent advances in biomaterials and stem cell applications, tissue engineering approaches are working towards a recapitulation of this phenomenon. In this review, we describe the elements that distinguish fetal scarless and adult scarring wound healing, and discuss current trends in tissue engineering aimed at achieving scarless tissue regeneration.

引用

页码：1494 / 1507

页数：14

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