Case-control Study of Methylenetetrahydrofolate Reductase Mutations and Hyperhomocysteinemia and Risk of Stroke

被引：16
|
作者：
Almawi, Wassim Y. [1 ]
Khan, Abdulmajeed [2 ]
Al-Othman, Sara S. [1 ]
Bakhiet, Moiz [1 ,2 ]
机构：
[1] Arabian Gulf Univ, Coll Med & Med Sci, Manama, Bahrain
[2] Bahrain Def Forces Hosp, Royal Med Serv, Rifaa, Bahrain
来源：
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES | 2009年 / 18卷 / 05期
关键词：
Stroke; methylenetetrahydrofolate reductase; homocysteine; FACTOR-V-LEIDEN; ISCHEMIC-STROKE; HOMOCYSTEINE; POLYMORPHISM; METAANALYSIS; ASSOCIATION; G20210A; DISEASE; EVENTS;
D O I：
10.1016/j.jstrokecerebrovasdis.2008.12.003
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The association of factor V-Leiden and methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C mutations with stroke was investigated in 118 patients with stroke and 120 control subjects. MTHFR 677TT (P < .001) and 1298CC (P < .001), but not factor V-Leiden (P = .179), genotypes were associated with stroke. The C677T but not A1298C MTHFR mutation was associated with elevated homocysteine levels in patients and control Subjects. In addition to hypertension, the significant predictors for stroke were MTHFR 677CT and TT and A1298CC genotypes, together with hyperhomocysteinemia, indicating a synergistic effect of MTHFR mutations with elevated homocysteine and other risk factors in pathogenesis of stroke.
引用
收藏
页码：407 / 408
页数：2
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