Improved Effect of Pycnogenol® on Impaired Spatial Memory Function in Partial Androgen Deficiency Rat Model

被引：10
|
作者：
Hasegawa, Noboru [1 ]
Mochizuki, Miyako [1 ]
机构：
[1] Gifu Womens Univ, Fac Home Econ, Dept Hlth & Nutr, Gifu 5012592, Japan
来源：
PHYTOTHERAPY RESEARCH | 2009年 / 23卷 / 06期
关键词：
Pycnogenol (R); partial androgen deficiency of the aging male; testosterone; working memory; reference memory; radial arm maze; TESTOSTERONE; QUERCETIN; BONE; MASS; MEN;
D O I：
10.1002/ptr.2702
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The improved effect of Pycnogenol (R) on impaired spatial memory function was studied in orchidectomized rats. Endogenous testosterone levels were decreased by approximately one-half for 3 months after castration. In the radial arm maze, castration significantly impaired working and reference memory function without lowering motor function. Pycnogenol (R) increased the NGF content in the hippocampus and cortex, and improved the spatial memory impairment. These observations confirmed that diagnostic accuracy can be improved by Pycnogenol (R) in androgen-deficient rats. Copyright (c) 2009 John Wiley & Sons, Ltd.
引用
收藏
页码：840 / 843
页数：4
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