p-Cymene Complexes of Ruthenium(II) as Antitumor Agents

被引：19

作者：

Angeles Pujante-Galian, Maria ^{[1
]}

Perez, Sergio A. ^{[2
]}

Montalban, Mercedes G. ^{[2
]}

Carissimi, Guzman ^{[2
]}

Fuster, Marta G. ^{[2
]}

Villora, Gloria ^{[2
]}

Garcia, Gabriel ^{[1
]}

机构：

[1] Univ Murcia, Fac Chem, Inorgan Chem Dept, Reg Campus Int Excellence Campus Mare Nostrum, Murcia 30071, Spain

[2] Univ Murcia, Fac Chem, Chem Engn Dept, Reg Campus Int Excellence Campus Mare Nostrum, Murcia 30071, Spain

来源：

MOLECULES | 2020年 / 25卷 / 21期

关键词：

ruthenium; complexes; cytotoxicity; anticancer activity; MTT assay; ANTICANCER COMPLEXES; CROSS-RESISTANCE; ARENE COMPLEXES; METAL-COMPLEXES; HUMAN OVARIAN; DNA-BINDING; CYTOTOXICITY; REACTIVITY; LIGANDS; DRUGS;

D O I：

10.3390/molecules25215063

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this work, the cytotoxic behavior of six ruthenium(II) complexes of stoichiometry [(eta(6)-p-cymene)RuCl2L] (I-VI), L = 4-cyanopyridine (I), 2-aminophenol (II), 4-aminophenol (III), pyridazine (IV), and [(eta(6)-p-cymene)RuClL2]PF6; L = cyanopyridine (V), L = 2-aminophenol(VI) towards three cell lines was studied. Two of them, HeLa and MCF-7, are human carcinogenic cells from cervical carcinoma and human breast cancer, respectively. A comparison with healthy cells was carried out with BGM cells which are monkey epithelial cells of renal origin. The behavior of complex II exhibits selectivity towards healthy cells, which is a promising feature for use in cancer treatment since it might reduce the side effects of most current therapies.

引用

页数：12

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