lncRNA LEF1-AS1 Promotes Malignancy in Non-Small-Cell Lung Cancer by Modulating the miR-489/SOX4 Axis

被引：35
|
作者：
Yang, Jiansheng [1 ]
Lin, Xianbin [1 ]
Jiang, Wentan [1 ]
Wu, Jingyang [1 ]
Lin, Liangan [1 ]
机构：
[1] Fujian Med Univ, Affiliated Hosp 2, Dept Thorac Surg, Quanzhou 362000, Fujian, Peoples R China
来源：
DNA AND CELL BIOLOGY | 2019年 / 38卷 / 09期
关键词：
non-small-cell lung cancer (NSCLC); LEF1-AS1; EMT; lncRNA; miR-489; LONG-NONCODING RNA; SOX4;
D O I：
10.1089/dna.2019.4717
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Increasing evidence has indicated that long noncoding RNAs (lncRNAs) could participate in diverse cancers. Among these, lymphoid enhancer-binding factor 1 antisense RNA 1 (LEF1-AS1) was recently identified as an oncogenic lncRNA, but little is known about its function in non-small-cell lung cancer (NSCLC). In the present study, we found that LEF1-AS1 was markedly upregulated in lung cancer tissues and could promote NSCLC cell proliferation and migration in vivo and in vitro. LEF1-AS1 could bind with miR-489 and further negatively regulate miR-489 to promote SRY-related HMG box transcription factor 4 (SOX4) expression. In conclusion, these data suggested that LEF1-AS1 promoted NSCLC tumorigenesis dependent on the miR-489-SOX4 axis and implicated the potential application of LEF1-AS1 for the prognosis and treatment of NSCLC.
引用
收藏
页码：1013 / 1021
页数：9
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