Anxiolytic effects of Echium amoenum on the elevated plus-maze model of anxiety in mice

被引：66
|
作者：
Rabbani, M
Sajjadi, SE
Vaseghi, G
Jafarian, A
机构：
[1] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Esfahan, Iran
[2] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Pharmacognosy, Esfahan, Iran
来源：
FITOTERAPIA | 2004年 / 75卷 / 05期
关键词：
Echium amoenum; anxiety; elevated plus-maze;
D O I：
10.1016/j.fitote.2004.04.004
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The ethanolic extract of Echium amoenum flowers at the dose of 50 mg/kg increased the percentage of time-spent and the percentage of arm entries in the open arms of the elevated plus-maze (EPM) and decreased the percentage of time-spent in the closed arms of EPM. Moreover, it prolonged the ketamine-induced latency to sleep but had no significant effects on total sleeping time induced by ketamine. Also, the locomotor activity was affected but not to the same extent as observed for diazepam. These results suggested that the extract of E. amoenum seems to possess anxiolytic effect with lower sedative activity than that of diazepam. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：457 / 464
页数：8
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