Manganese catalyzed reductive amination of aldehydes using hydrogen as a reductant

被引：1
|
作者：
Wei, Duo [1 ]
Bruneau-Voisine, Antoine [1 ,2 ]
Valyaev, Dmitry A. [2 ]
Lugan, Noel [2 ]
Sortais, Jean-Baptiste [2 ,3 ]
机构：
[1] Univ Rennes, CNRS, UMR 6226, ISCR, F-35000 Rennes, France
[2] Univ Toulouse, CNRS, UPS, LCC, Toulouse, France
[3] Inst Univ France, 1 Rue Descartes, F-75231 Paris 05, France
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 34期
关键词：
PNP PINCER COMPLEXES; PRIMARY ALCOHOLS; SUSTAINABLE SYNTHESIS; AMINE SYNTHESIS; N-METHYLATION; PRE-CATALYST; KETONES; HYDROSILYLATION; METHANOL; EFFICIENT;
D O I：
10.1039/C8CC01787E
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A one-pot two-step procedure was developed for the alkylation of amines via reductive amination of aldehydes using molecular dihydrogen as a reductant in the presence of a manganese pyridinyl-phosphine complex as a pre-catalyst. After the initial condensation step, the reduction of imines formed in situ is performed under mild conditions (50-100 degrees C) with 2 mol% of catalyst and 5 mol% of tBuOK under 50 bar of hydrogen. Excellent yields (>90%) were obtained for a large combination of aldehydes and amines (40 examples), including aliphatic aldehydes and amino-alcohols.
引用
收藏
页码：4302 / 4305
页数：4
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