CD1d expression is higher in chronic lymphocytic leukemia patients with unfavorable prognosis

被引：25
|
作者：
Bojarska-Junak, Agnieszka [1 ]
Hus, Iwona [2 ]
Chocholska, Sylwia [3 ]
Tomczak, Waldemar [3 ]
Wos, Justyna [1 ]
Czubak, Pawel [4 ]
Putowski, Lechoslaw [4 ]
Rolinski, Jacek [1 ]
机构：
[1] Med Univ Lublin, Chair & Dept Clin Immunol, PL-20093 Lublin, Poland
[2] Med Univ Lublin, Dept Clin Transplantol, PL-20093 Lublin, Poland
[3] Med Univ Lublin, Dept Haematooncol & Bone Marrow Transplantat, PL-20093 Lublin, Poland
[4] Med Univ Lublin, Chair & Dept Gynaecol & Gynaecol Endocrinol, PL-20093 Lublin, Poland
来源：
LEUKEMIA RESEARCH | 2014年 / 38卷 / 04期
关键词：
CLL; CD1d; iNKT; CD3; zeta; ZAP; 70; CD38; ZETA-CHAIN EXPRESSION; TUMOR-CELLS; T-CELL; LEF-1; PROGRESSION; IMMUNITY; SUBSETS; ZAP-70; TARGET; GAMMA;
D O I：
10.1016/j.leukres.2013.12.015
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Through the analysis of CD1d expression by flow cytometry and qRT-PCR we showed lower CD1d molecule and CD1d mRNA expression in B cells of CLL patients than of healthy controls. The frequency of CD1d(+)/CD19(+) cells, CD1d staining intensity and CD1d transcript levels increased with the disease stage. CD1d expression was positively associated with ZAP-70 and CD38 expressions as well as with unfavourable cytogenetic changes. We established the relationship between high CD1d expression and shorter time to treatment and overall survival. We observed that CD1d expression in individual patients significantly changed over time. The percentage of CD1d+/CD19+ cells inversely correlated with the percentage of iNKT cells. (c) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：435 / 442
页数：8
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