Triterpenoid constituents isolated from the bark of Abies sachalinensis

被引：34

作者：

Wada, S

Iida, A

Tanaka, R

机构：

[1] Osaka Univ Pharmaceut Sci, Takatsuki, Osaka 5691094, Japan

[2] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 11期

关键词：

D O I：

10.1021/np020282b

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new lanostane-type triterpenoids (1-3) were isolated from the bark of Abies sachalinensis along with a known compound (4). The structures of 1-4 were characterized by spectroscopic methods including NMR and MS. Compound 4 and some derivatives were tested for inhibitory effects on in vitro DNA topoisomerases I and II and found to be selective catalytic inhibitors of topoisomerase II activity with IC50 values in the range 43-76 muM.

引用

页码：1657 / 1659

页数：3

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