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Low penetrance genetic polymorphisms as potential biomarkers for colorectal cancer predisposition
被引:31
|作者:
Tan, Shing Cheng
[1
]
机构:
[1] Univ Kebangsaan Malaysia, UKM Med Mol Biol Inst, Jalan Yaacob Latiff, Kuala Lumpur 56000, Malaysia
来源:
关键词:
colon;
rectal cancer;
epidemiology;
gene polymorphism;
tumor biology;
OXIDATIVE DNA-DAMAGE;
VITAMIN-D-RECEPTOR;
HOGG1 SER326CYS POLYMORPHISM;
NUCLEOTIDE EXCISION-REPAIR;
CCND1 G870A POLYMORPHISM;
POLYPOSIS-COLI PROTEIN;
RETINOID-X-RECEPTOR;
NF-KAPPA-B;
CYCLIN D1;
MISMATCH REPAIR;
D O I:
10.1002/jgm.3010
中图分类号:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号:
071005 ;
0836 ;
090102 ;
100705 ;
摘要:
Colorectal cancer is a leading form of cancer in both males and females. Early detection of individuals at risk of colorectal cancer allows proper treatment and management of the disease to be implemented, which can potentially reduce the burden of colorectal cancer incidence, morbidity and mortality. In recent years, the role of genetic susceptibility factors in mediating predisposition to colorectal cancer has become more and more apparent. Identification of high-frequency, low-penetrance genetic polymorphisms associated with the cancer has therefore emerged as an important approach which can potentially aid prediction of colorectal cancer risk. However, the overwhelming amount of genetic epidemiology data generated over the past decades has made it difficult for one to assimilate the information and determine the exact genetic polymorphisms that can potentially be used as biomarkers for colorectal cancer. This review comprehensively consolidates, based primarily on results from meta-analyses, the recent progresses in the search of colorectal cancer-associated genetic polymorphisms, and discusses the possible mechanisms involved.
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页数:18
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