Design and synthesis of anti-cancer cyclopeptides containing triazole skeleton

被引：29

作者：

Tahoori, Fatemeh ^{[1
]}

Balalaie, Saeed ^{[1
]}

Sheikhnejad, Reza ^{[2
]}

Sadjadi, Mahnaz ^{[2
]}

Boloori, Parvin ^{[2
]}

机构：

[1] KN Toosi Univ Technol, Peptide Chem Res Ctr, Tehran, Iran

[2] Tofigh Daru Res & Eng Co, Tehran 37515375, Iran

来源：

AMINO ACIDS | 2014年 / 46卷 / 04期

关键词：

Ugi ligation; Ligation of peptides; Anti-cancer activity; Cyclopeptides; Click reaction; Huisgen 1,3-Dipolar reaction; CLICK CHEMISTRY; MULTICOMPONENT REACTIONS; STEREOSELECTIVE-SYNTHESIS; AMINO-ACIDS; SOLID-PHASE; CYCLOADDITION; AZIDE; COORDINATION; EFFICIENT; ANALOGS;

D O I：

10.1007/s00726-013-1663-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe the design and synthesis of some hypothetical heptapeptides specifically to overcome the neoplastic activity of ras oncogene and their anti-cancer activities were studied. To improve the anti-cancer activity of the synthesized peptides, their structure modifications were done based on a sequential Ugi/Huisgen 1,3-Dipolar cyclization reaction. The cyclopeptides which contained triazole skeleton showed significant anti-cancer activity against cancer cells with mutated ras oncogene such as A549, PC3 and C26 cells. This study clearly shows the importance of triazole skeleton in biological activity of the peptides. It might be possible to overcome the difficulties involved in making complex peptides by employing this elegant chemistry.

引用

页码：1033 / 1046

页数：14

共 50 条

[1] Design and synthesis of anti-cancer cyclopeptides containing triazole skeleton
Fatemeh Tahoori
Saeed Balalaie
Reza Sheikhnejad
Mahnaz Sadjadi
Parvin Boloori
Amino Acids, 2014, 46 : 1033 - 1046
[2] Design and synthesis of novel 1,2,3-triazole derivatives of coronopilin as anti-cancer compounds
Khazir, Jabeena
Hyder, Irfan
Gayatri, J. Laxmi
Yandrati, Leela Prasad
Nalla, Naresh
Chasoo, Gousia
Mahajan, Ajay
Saxena, A. K.
Alam, M. S.
Qazi, G. N.
Kumar, Halmuthur M. Sampath
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 82 : 255 - 262
[3] Synthesis and biological evaluation of novel pyrazoline derivatives containing indole skeleton as anti-cancer agents targeting topoisomerase II
Song, Yali
Feng, Siran
Feng, Jiajia
Dong, Jinjiao
Yang, Kan
Liu, Zhenming
Qiao, Xiaoqiang
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 200
[4] DESIGN AND SYNTHESIS OF NOVEL INDOLOCARBAZOLE DERIVATIVES AS ANTI-CANCER AGENTS
Pierce, Larry T.
Cahill, Michael M.
McCarthy, Florence O.
DRUGS OF THE FUTURE, 2009, 34 : 100 - 100
[5] TRANSLESION SYNTHESIS PATHWAY AS TARGET FOR ANTI-CANCER DRUG DESIGN
Korzhnev, Dmitry
PROTEIN SCIENCE, 2019, 28 : 42 - 42
[6] Design, Synthesis, and Evaluation of Genistein Analogues as Anti-Cancer Agents
Xiong, Pahoua
Wang, Rubing
Zhang, Xiaojie
Dela Torre, Eduardo
Leon, Francisco
Zhang, Qiang
Zheng, Shilong
Wang, Guangdi
Chen, Qiao-Hong
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2015, 15 (09) : 1197 - 1203
[7] Design and Synthesis of Flavonoidal Ethers and Their Anti-Cancer Activity In Vitro
Jin, Lu
Wang, Meng-Ling
Lv, Yao
Zeng, Xue-Yi
Chen, Chao
Ren, Hai
Luo, Heng
Pan, Wei-Dong
MOLECULES, 2019, 24 (09):
[8] Synthesis of PLGA nanoparticles containing Auraptene and evaluation of their anti-cancer effects
Bedan, Suha Lefta
Es-haghi, Ali
Zare-Zardini, Hadi
NANOMEDICINE JOURNAL, 2025, 12 (02) : 324 - 334
[9] Novel Triazole Derivatives Containing Different Ester Skeleton: Design, Synthesis, Biological Evaluation and Molecular Docking
Han, Xiaoyan
Wang, Shumin
Zhang, Na
Ren, Liwen
Sun, Xiaoyang
Song, Yali
Wang, Jinhua
Xiao, Bin
CHEMICAL & PHARMACEUTICAL BULLETIN, 2020, 68 (01) : 64 - 69
[10] Design and Synthesis of Tetrahydroisoquinoline Derivatives as Anti-Angiogenesis and Anti-Cancer Agents
Gangapuram, Madhavi
Eyunni, Suresh
Zhang, Wang
Redda, Kinfe K.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2021, 21 (18) : 2505 - 2511

← 1 2 3 4 5 →