Factors Associated with Rebleeding in Patients with Peptic Ulcer Bleeding: Analysis of the Korean Peptic Ulcer Bleeding (K-PUB) Study

被引：22

作者：

Kim, Joon Sung ^{[1
]}

Kim, Byung-Wook ^{[1
]}

Park, Sung Min ^{[1
]}

Shim, Ki-Nam ^{[2
]}

Jeon, Seong Woo ^{[3
]}

Kim, Sang-Wook ^{[4
]}

Lee, Yong Chan ^{[5
]}

Moon, Hee Seok ^{[6
]}

Lee, Si Hyung ^{[7
]}

Jung, Woon Tae ^{[8
]}

Kim, Jin Il ^{[9
]}

Kim, Kyoung Oh ^{[10
]}

Park, Jong-Jae ^{[11
]}

Chung, Woo Chul ^{[12
]}

Kim, Jeong Hwan ^{[13
]}

Baik, Gwang Ho ^{[14
]}

Oh, Jung Hwan ^{[15
]}

Kim, Sun Moon ^{[16
]}

Kim, Hyun Soo ^{[17
]}

Yang, Chang Heon ^{[18
]}

Jung, Jin Tae ^{[19
]}

Lim, Chul Hyun ^{[20
]}

Song, Hyun Joo ^{[21
]}

Kim, Yong Sik ^{[22
]}

Ha Kim, Gwang ^{[23
]}

Kim, Jie-Hyun ^{[24
]}

Chung, Jae-Il ^{[25
]}

Lee, Jun Haeng ^{[26
]}

Choi, Min Ho ^{[27
]}

Choi, Jong-Kyoung ^{[28
]}

机构：

[1] Catholic Univ Korea, Coll Med, Incheon St Marys Hosp, Div Gastroenterol,Dept Internal Med, 56 Dongsu Ro, Incheon 21431, South Korea

[2] Ewha Womans Univ, Dept Internal Med, Sch Med, Seoul, South Korea

[3] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea

[4] Chonbuk Natl Univ, Dept Internal Med, Med Sch, Jeonju, South Korea

[5] Yonsei Univ, Severance Hosp, Dept Internal Med, Div Gastroenterol,Coll Med, Seoul, South Korea

[6] Chungnam Natl Univ, Dept Internal Med, Sch Med, Daejeon, South Korea

[7] Yeungnam Univ, Dept Internal Med, Sch Med, Daegu, South Korea

[8] Gyeongsang Natl Univ, Dept Internal Med, Sch Med, Jinju, South Korea

[9] Catholic Univ Korea, Yeouido St Marys Hosp, Dept Internal Med, Coll Med, Seoul, South Korea

[10] Gachon Univ, Dept Internal Med, Gil Med Ctr, Incheon, South Korea

[11] Korea Univ, Dept Internal Med, Div Gastroenterol, Guro Hosp, Seoul, South Korea

[12] Catholic Univ Korea, St Vincents Hosp, Dept Internal Med, Coll Med, Suwon, South Korea

[13] Konkuk Univ, Dept Internal Med, Sch Med, Seoul, South Korea

[14] Hallym Univ, Dept Internal Med, Coll Med, Chunchon, South Korea

[15] Catholic Univ Korea, St Paul Hosp, Dept Internal Med, Coll Med, Seoul, South Korea

[16] Konyang Univ Hosp, Dept Internal Med, Daejeon, South Korea

[17] Chonnam Natl Univ, Dept Internal Med, Med Sch, Gwangju, South Korea

[18] Dongguk Univ, Dept Internal Med, Coll Med, Gyeongju, South Korea

[19] Daegu Catholic Univ, Dept Internal Med, Div Gastroenterol, Coll Med, Daegu, South Korea

[20] Catholic Univ Korea, Seoul St Marys Hosp, Dept Internal Med, Coll Med, Seoul, South Korea

[21] Jeju Natl Univ, Dept Internal Med, Sch Med, Jeju, South Korea

[22] Eulji Univ, Dept Internal Med, Coll Med, Daejeon, South Korea

[23] Pusan Natl Univ, Dept Internal Med, Sch Med, Busan, South Korea

[24] Yonsei Univ, Dept Internal Med, Gangnam Severance Hosp, Coll Med, Seoul, South Korea

[25] Sahmyook Med Ctr, Dept Internal Med, Seoul, South Korea

[26] Sungkyunkwan Univ, Sch Med, Dept Med, Samsung Med Ctr, Seoul, South Korea

[27] Hallym Univ, Coll Med, Dongtan Sacred Heart Hosp, Dept Internal Med, Hwaseong, South Korea

[28] Natl Med Ctr, Dept Internal Med, Seoul, South Korea

来源：

GUT AND LIVER | 2018年 / 12卷 / 03期

关键词：

Peptic ulcer hemorrhage; Rebleeding; Risk factors; UPPER-GASTROINTESTINAL HEMORRHAGE; CONSENSUS RECOMMENDATIONS; ENDOSCOPIC HEMOSTASIS; IMPROVED OUTCOMES; OUTPATIENT CARE; MANAGEMENT; THERAPY; METAANALYSIS; OMEPRAZOLE; GUIDELINE;

D O I：

10.5009/gnl17138

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/Aims: Rebleeding is associated with mortality in patients with peptic ulcer bleeding (PUB), and risk stratification is important for the management of these patients. The purpose of our study was to examine the risk factors associated with rebleeding in patients with PUB. Methods: The Korean Peptic Ulcer Bleeding registry is a large prospectively collected database of patients with PUB who were hospitalized between 2014 and 2015 at 28 medical centers in Korea. We examined the basic characteristics and clinical outcomes of patients in this registry. Univariate and multivariate analyses were performed to identify the factors associated with rebleeding. Results: In total, 904 patients with PUB were registered, and 897 patients were analyzed. Rebleeding occurred in 7.1% of the patients (64), and the 30-day mortality was 1.0% (nine patients). According to the multivariate analysis, the risk factors for rebleeding were the presence of co-morbidities, use of multiple drugs, albumin levels, and hematemesis/hematochezia as initial presentations. Conclusions: The presence of co-morbidities, use of multiple drugs, albumin levels, and initial presentations with hematemesis/hematochezia can be indicators of rebleeding in patients with PUB. The wide use of proton pump inhibitors and prompt endoscopic interventions may explain the low incidence of rebleeding and low mortality rates in Korea.

引用

页码：271 / 277

页数：7

共 50 条

[1] Comparison of 4 scoring systems for predicting clinical outcomes in Korean patients with peptic ulcer bleeding: K-PUB study analysis
Kim, Byung-Wook
Gweon, Tae-Geun
Park, Sung Min
Kim, Joon Sung
Kim, Young Wook
Kim, Gi Jun
[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2016, 31 : 84 - 84
[2] The study of NSAID associated ulcer bleeding and peptic ulcer bleeding
Tao, Jin
Li, Leijia
Wu, Bin
[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2013, 28 : 741 - 741
[3] Predictors of rebleeding in patients with peptic ulcer bleeding: nationwide study in Korea
Sung-Min, P.
Joon-Sung, K.
Byung-Wook, K.
Ki-Nam, S.
Sang-Wook, K.
Seong-Woo, J.
Yong-Chan, L.
Hee-Seok, M.
Si-Hyng, L.
Jong-Jae, P.
Jin-Il, K.
Kyoung-Oh, K.
Woon-Tae, J.
Jeong-Hwan, K.
Woo-Chul, C.
Sun-Moon, K.
Hyun-Soo, K.
Gwang-Ho, B.
Jung-Hwan, O.
Chang-Heon, Y.
Hyun-Joo, S.
Jin-Tae, J.
Yong-Sik, K.
Gwang-Ha, K.
Jun-Haeng, L.
Jie-Hyun, K.
Jae-Il, C.
Jong-Kyoung, C.
Min-Ho, C.
[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2015, 30 : 17 - 18
[4] Impact of Hemodialysis on Peptic Ulcer Bleeding-Study to Identify Risk Factors for Peptic Ulcer Rebleeding and Mortality-
Yamada, Tomoharu
Toda, Nobuo
Kawamura, Satoshi
Hayata, Yuki
Karasawa, Yuki
Yamagami, Mari
Ito, Daisaku
Kawanishi, Koki
Sato, Kouki
Kojima, Kentaro
Ohki, Takamasa
Seki, Michiharu
Tagawa, Kazumi
[J]. GASTROINTESTINAL ENDOSCOPY, 2015, 81 (05) : AB231 - AB231
[5] Risk factors analysis of the peptic ulcer bleeding
Kim, IH
Kim, PS
Lee, DH
Yoo, JG
Choi, W
Kim, HG
Kim, YS
[J]. GASTROENTEROLOGY, 1999, 116 (04) : A214 - A214
[6] Pantoprazole for the Treatment of Peptic Ulcer Bleeding and Prevention of Rebleeding
van Rensburg, Christo J.
Cheer, Susan
[J]. CLINICAL MEDICINE INSIGHTS-GASTROENTEROLOGY, 2012, 5 : 51 - 60
[7] Initial factors predicting rebleeding and death in bleeding peptic ulcer disease
Al-Akeely, MH
Alam, MK
Al-Salamah, SM
Abdu, MA
Al-Teimi, IN
Mohammed, AA
[J]. SAUDI MEDICAL JOURNAL, 2004, 25 (05) : 642 - 647
[8] BLEEDING PEPTIC ULCER
WARDMCQU.JN
[J]. BRITISH MEDICAL JOURNAL, 1966, 1 (5490): : 800 - &
[9] THE BLEEDING PEPTIC ULCER
不详
[J]. LANCET, 1946, 251 (OCT26): : 605 - 607
[10] Predictive factors for rebleeding in patients with peptic ulcer bleeding after multipolar electrocoagulation - A retrospective analysis
Li, HJ
Tseng, GY
Lo, WC
Lee, FY
Perng, CL
Chang, FY
Lee, SD
[J]. JOURNAL OF CLINICAL GASTROENTEROLOGY, 1998, 26 (02) : 113 - 116

← 1 2 3 4 5 →