Cathodic adsorptive stripping voltammetry of drotaverine hydrochloride and its determination in tablets and human urine by differential pulse voltammetry

被引：13
|
作者：
Zayed, S. I. M. [1 ]
Issa, Y. M. [2 ]
机构：
[1] Beni Suef Univ, Fac Ind Educ, Bani Suwayf, Egypt
[2] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt
来源：
BIOELECTROCHEMISTRY | 2009年 / 75卷 / 01期
关键词：
Drotaverine hydrochloride; Absorptive stripping voltammetry; HMDE; Pharmaceutical dosage form; Human urine; LIQUID-CHROMATOGRAPHIC METHOD; FLOW-INJECTION ANALYSIS; PHARMACEUTICAL-PREPARATIONS; SPECTROPHOTOMETRIC DETERMINATION; HUMAN PLASMA; ELECTRODES; PAPAVERINE; DRUGS; HCL;
D O I：
10.1016/j.bioelechem.2008.11.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The stripping voltammetric behaviour of drotaverine hydrochloride (DvCl) was studied using a hanging mercury drop electrode (HMDE). The adsorptive stripping response has been evaluated with respect to pH, accumulation time, accumulation potential, scan rate and other variables. Differential pulse DP mode; over the potential range -400 to -1200 mV, is used in the presence of 0.04 M Britton-Robinson buffer pH 2. Cyclic voltammetric study indicates that the reduction process is irreversible and controlled by adsorption. The response of DP technique is linear over the concentration range 21.70-257.34 ng/ml. Limit of detection and limit of quantification were 3.15 and 10.50 ng/ml, respectively. The proposed method was successfully applied for the determination of the drug in commercial tablets and spiked human urine samples. (c) 2008 Elsevier B.V. All rights reserved.
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页码：9 / 12
页数：4
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