Design and simulation of the angle-ended fiber integrated into optoelectronic tweezers chip

A novel angle-ended fiber integrated into the optoelectronic tweezers (OET) chip is proposed to trap large amounts of cells or microorganism from liquid medium. The spotlight from the multimode fiber, which has a core diameter of about 40 mu m and an oblique angle of 40 degrees, is used instead of LCD or DMD to generate non-uniform electric field. The fabrication process and method relative to angle-ended fiber is also described in this paper. The light wave based on finite element method (FEM) can calculate the propagation of refracted light into the fluid. The present paper describes the theoretical principles underlying such as electric and fluid field, and describes a simple mechanical analysis based on molecular dynamics for capturing of the flowing cells. The results indicated that optically induced dielectrophoresis (ODEP) force exerted on the red blood cells to drive them moving on the bottom of the OET chip when the velocity of cells are 50 mu m/s. Meanwhile, it is possible to develop angle-ended fiber array to form a few virtual electrodes in OET chip rather than a single fiber. Finally, the device expected to show good results from imitating internal blood flow of human organs in the lab on a chip. (C) 2015 Elsevier GmbH. All rights reserved.