Efavirenz Treatment and False-Positive Results in Benzodiazepine Screening Tests

被引：11

作者：

Blank, Antje ^{[1
]}

Hellstern, Victoria ^{[1
]}

Schuster, Dieter ^{[3
]}

Hartmann, Martin ^{[2
]}

Matthee, Anne K. ^{[1
]}

Burhenne, Juergen ^{[1
]}

Haefeli, Walter E. ^{[1
]}

Mikus, Gerd ^{[1
]}

机构：

[1] Univ Heidelberg Hosp, Dept Internal Med Clin Pharmacol & Pharmacoepidemi, D-69120 Heidelberg, Germany

[2] Univ Heidelberg Hosp, Dept Dermatol, D-69120 Heidelberg, Germany

[3] Schwerpunktpraxis Mannheim, Mannheim, Germany

来源：

CLINICAL INFECTIOUS DISEASES | 2009年 / 48卷 / 12期

关键词：

URINE; DRUGS;

D O I：

10.1086/599109

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the effect of efavirenz treatment on the results of drug screening tests of urine samples obtained from 100 patients infected with human immunodeficiency virus. Of 50 patients who received efavirenz, 49 tested positive for benzodiazepines in >= 1 drug screening test, whereas of 50 patients who did not receive efavirenz, only 1 tested positive for benzodiazepines in >= 1 drug screening test. The major metabolite 8-hydroxy-efavirenz is responsible for this cross-reactivity.

引用

页码：1787 / 1789

页数：3

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