Dietary conjugated linoleic acid modifies the brain endocannabinoid system in mice

被引：10
|
作者：
Tsuyama, Shoichiro [1 ]
Oikawa, Daichi [1 ]
Tsuji, Yukiko [2 ]
Akimoto, Yoriko [1 ]
Jikuya, Hiroyuki [2 ]
Furuse, Mitsuhiro [1 ]
机构：
[1] Kyushu Univ, Grad Sch Bioresources & Bioenvironm Sci, Lab Adv Anim & Marine Bioresources, Fukuoka 8128581, Japan
[2] Kyushu Univ, Bioarchitecture Ctr, Lab Metab Architecture Design, Fukuoka 8128581, Japan
来源：
NUTRITIONAL NEUROSCIENCE | 2009年 / 12卷 / 04期
关键词：
endocannabinoid; conjugated linoleic acid; LC-MS; brain; mouse; FOOD-INTAKE; RAT-BRAIN; EXPRESSION; LIVER;
D O I：
10.1179/147683009X423373
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Conjugated linoleic acid (CLA) has a role of biogenic regulation through modifying prostaglandin production. However, its effects on related metabolites of arachidonate remain unclear. Therefore, the effects of CLA on brain endocannabinoid content as well as its analogs were investigated. Mice (3-week-old), provided with diets containing 3% linoleic acid or 3% CLA for 4 weeks, were sacrificed and lipids were extracted from their cerebral cortex and hypothalamus. The amounts of N-arachidonoyl-ethanolamide, 2-arachidonoyl-glycerol (2-AG), oleoyl-ethanolamide and palmitoylethanolamide were determined quantitatively by LC-MS. The 2-AG level in the cerebral cortex was significantly decreased by CLA treatment, but the other compounds were unaffected in the cerebral cortex and hypothalamus. The present study indicated that dietary CLA site-selectively decreases 2-AG in the cerebral cortex.
引用
收藏
页码：155 / 159
页数：5
相关论文
共 50 条
  • [1] Dietary conjugated linoleic acid reciprocally modifies ketogenesis and lipid secretion by the rat liver
    Sakono, M
    Miyanaga, F
    Kawahara, S
    Yamauchi, K
    Fukuda, N
    Watanabe, K
    Iwata, T
    Sugano, M
    [J]. LIPIDS, 1999, 34 (09) : 997 - 1000
  • [2] Effects of Dietary Conjugated Linoleic Acid and Biopolymer Encapsulation on Lipid Metabolism in Mice
    Hur, Sun Jin
    Kim, Doo Hwan
    Chun, Se Chul
    Lee, Si Kyung
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 14 (04) : 6848 - 6862
  • [3] Dietary coconut oil and conjugated linoleic acid reduce body fat in mice
    Hargrave, K. M.
    Miner, J. L.
    [J]. JOURNAL OF ANIMAL SCIENCE, 2004, 82 : 422 - 422
  • [4] Dietary coconut oil and conjugated linoleic acid reduce body fat in mice
    Hargrave, K. M.
    Miner, J. L.
    [J]. POULTRY SCIENCE, 2004, 83 : 422 - 422
  • [5] Expression of Adipose MicroRNAs Is Sensitive to Dietary Conjugated Linoleic Acid Treatment in Mice
    Parra, Pilar
    Serra, Francisca
    Palou, Andreu
    [J]. PLOS ONE, 2010, 5 (09):
  • [6] Effects of dietary conjugated linoleic acid on the expression of uncoupling proteins in mice and rats
    Ealey, Kafi N.
    El-Sohemy, Ahmed
    Archer, Michael C.
    [J]. 2002, American Oil Chemists Society (37)
  • [7] Dietary coconut oil and conjugated linoleic acid reduce body fat in mice
    Hargrave, K. M.
    Miner, J. L.
    [J]. JOURNAL OF DAIRY SCIENCE, 2004, 87 : 422 - 422
  • [8] Mice do not accumulate muscle lipid in response to dietary conjugated linoleic acid
    Kanosky, K. M.
    Ippagunta, S.
    Barnes, K. M.
    [J]. JOURNAL OF ANIMAL SCIENCE, 2013, 91 (10) : 4705 - 4712
  • [9] Effects of dietary conjugated linoleic acid on the expression of uncoupling proteins in mice and rats
    Ealey, KN
    El-Sohemy, A
    Archer, MC
    [J]. LIPIDS, 2002, 37 (09) : 853 - 861
  • [10] Dietary conjugated linoleic acid and body composition
    Wang, YW
    Jones, PJH
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2004, 79 (06): : 1153S - 1158S
12345