A Case of Kindler Syndrome

Kindler syndrome is a rare genetic disorder, acral blistering and photosensitivity appears from birth, followed by progressive poikiloderma and cutaneous atrophy. Kindler syndrome is caused by mutations in KIND-1 gene encoding the protein kindlin-1 which is involved in the attachment of the actin cytoskeleton to the extracellular matrix basal keratinocytes. Here we report a 18-year-old woman presented with generalized poikiloderma, webbing of the toes and fingers, palmoplantar hyperkeratosis, nail dystrophy periodontitis and ectropione with a history of blister formation in early infant. (Turkderm 2009; 43: 68-9)