Synthesis of 10-phenyl-[1,2,4]triazolo[1,5-b] [2,7]naphthyridin-5(3H)-one derivatives

被引：1

作者：

Xu, Feng ^{[1
]}

Yang, Zhen-Zhen ^{[1
]}

Xi, Li-Min ^{[1
]}

Jiang, Jun-Rong ^{[1
]}

Ke, Zhong-Lu ^{[1
]}

Wu, Han-Gui ^{[1
]}

机构：

[1] Taizhou Vocat & Tech Coll, Biopharmaceut Res & Dev Ctr, Taizhou 318000, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2014年 / 05期

关键词：

triazole; naphthyridinone; crystal structure; synthesis of 10-phenyl-[1,2,4] triazolo[1,5-b][2,7]naphthyridin-5(3H)-one derivatives; INDOLE ALKALOIDS; LOPHOCLADINES;

D O I：

10.3184/174751914X13976543689677

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several new 10-phenyl-[1,2,4] triazolo[1,5-b][2,7] naphthyridin-5(3H)-one derivatives were synthesised by condensation of 2,3-diamino-4-phenyl-2,7-naphthyridin-1(2H)-one with aldehydes and also with acid anhydrides. Their structures were confirmed by H-1 NMR, C-13 NMR, IR, mass spectra and elemental analysis. The key starting material 4-[a-cyano(phenyl) methyl] nicotinic acid was easily cyclised to give 3-amino-4-phenyl-1H-pyrano[3,4-c] pyridin-1-one under alkaline conditions, the structure of which was confirmed by X-ray crystallography following conversion to the corresponding N, N-dimethylformamidine derivative.

引用

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页码：317 / 321

页数：5

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