Effects of sequential osteoporosis treatments on trabecular bone in adult rats with low bone mass

被引:16
|
作者
Amugongo, S. K. [1 ,2 ]
Yao, W. [1 ,2 ]
Jia, J. [1 ,2 ]
Lay, Y. -A. E. [1 ,2 ]
Dai, W. [1 ,2 ]
Jiang, L. [1 ,2 ]
Walsh, D. [1 ,2 ]
Li, C. -S. [3 ]
Dave, N. K. N. [4 ,5 ]
Olivera, D. [4 ,5 ]
Panganiban, B. [4 ,5 ]
Ritchie, R. O. [4 ,5 ]
Lane, N. E. [1 ,2 ]
机构
[1] Univ Calif Davis, Med Ctr, Ctr Musculoskeletal Hlth, Sacramento, CA 95817 USA
[2] Univ Calif Davis, Med Ctr, Dept Med, Sacramento, CA 95817 USA
[3] Univ Calif Davis, Dept Publ Hlth Sci, Div Biostat, Davis, CA 95616 USA
[4] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA
[5] Univ Calif Berkeley, Dept Mat Sci & Engn, Berkeley, CA 94720 USA
基金
美国国家卫生研究院;
关键词
Alendronate; Mass; Microarchitecture; Ovariectomy; Parathyroid hormone; Raloxifene; Strength; PARATHYROID-HORMONE; 1-84; MICRO-COMPUTED TOMOGRAPHY; AGED OVARIECTOMIZED RATS; VERTEBRAL FRACTURE RISK; POSTMENOPAUSAL WOMEN; BISPHOSPHONATE THERAPY; ANTIRESORPTIVE AGENTS; CANCELLOUS BONE; DRUG HOLIDAY; ALENDRONATE;
D O I
10.1007/s00198-014-2678-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We used an osteopenic adult ovariectomized (OVX) rat model to evaluate various sequential treatments for osteoporosis, using FDA-approved agents with complementary tissue-level mechanisms of action. Sequential treatment for 3 months each with alendronate (Aln), followed by PTH, followed by resumption of Aln, created the highest trabecular bone mass, best microarchitecture, and highest bone strength. Individual agents used to treat human osteoporosis reduce fracture risk by similar to 50-60 %. As agents that act with complementary mechanisms are available, sequential therapies that mix antiresorptive and anabolic agents could improve fracture risk reduction, when compared with monotherapies. We evaluated bone mass, bone microarchitecture, and bone strength in adult OVX, osteopenic rats, during different sequences of vehicle (Veh), parathyroid hormone (PTH), Aln, or raloxifene (Ral) in three 90- day treatment periods, over 9 months. Differences among groups were evaluated. The interrelationships of bone mass and microarchitecture endpoints and their relationship to bone strength were studied. Estrogen deficiency caused bone loss. OVX rats treated with Aln monotherapy had significantly better bone mass, microarchitecture, and bone strength than untreated OVX rats. Rats treated with an Aln drug holiday had bone mass and microarchitecture similar to the Aln monotherapy group but with significantly lower bone strength. PTH-treated rats had markedly higher bone endpoints, but all were lost after PTH withdrawal without follow-up treatment. Rats treated with PTH followed by Aln had better bone endpoints than those treated with Aln monotherapy, PTH monotherapy, or an Aln holiday. Rats treated initially with Aln or Ral, then switched to PTH, also had better bone endpoints, than monotherapy treatment. Rats treated with Aln, then PTH, and returned to Aln had the highest values for all endpoints. Our data indicate that antiresorptive therapy can be coupled with an anabolic agent, to produce and maintain better bone mass, microarchitecture, and strength than can be achieved with any monotherapy.
引用
收藏
页码:1735 / 1750
页数:16
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