The TWEAK-Fn14 pathway: A potent regulator of skeletal muscle biology in health and disease

被引：41

作者：

Tajrishi, Marjan M. ^{[1
]}

Zheng, Timothy S. ^{[2
]}

Burkly, Linda C. ^{[2
]}

Kumar, Ashok ^{[1
]}

机构：

[1] Univ Louisville, Sch Med, Louisville, KY 40202 USA

[2] Biogen Idec Inc, Dept Immunol, Cambridge, MA 02142 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2014年 / 25卷 / 02期

关键词：

Skeletal muscle atrophy; Regeneration; NF-kappa B; Tissue injury; Fibrosis; NF-KAPPA-B; WEAK INDUCER; APOPTOSIS TWEAK; SIGNALING PATHWAYS; MOLECULAR-MECHANISMS; PGC-1; COACTIVATORS; TARGETED ABLATION; MYOBLAST FUSION; TNF-ALPHA; ATROPHY;

D O I：

10.1016/j.cytogfr.2013.12.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

TNF-like weak inducer of apoptosis (TWEAK), a TNF superfamily ligand, and its bona fide receptor, the TNF receptor superfamily member fibroblast growth factor-inducible 14 (Fn14), represent a pivotal axis for shaping both physiological and pathological tissue responses to acute or chronic injury and disease. In recent years significant advances have been made in delineating the prominent role of TWEAK-Fn14 dyad in regulating skeletal muscle mass and metabolism. Also emerging from the broad study of tissue injury in skeletal muscle and other organs is the role of the TWEAK-Fn14 pathway in promoting fibrosis. This review article highlights recent advancements toward understanding how the TWEAK-Fn14 pathway regulates the response to various skeletal muscle insults and, more broadly, engages multiple mechanisms to drive tissue fibrosis. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：215 / 225

页数：11

共 50 条

[1] Controversies in TWEAK-Fn14 signaling in skeletal muscle atrophy and regeneration
Amy L. Pascoe
Amelia J. Johnston
Robyn M. Murphy
[J]. Cellular and Molecular Life Sciences, 2020, 77 : 3369 - 3381
[2] Controversies in TWEAK-Fn14 signaling in skeletal muscle atrophy and regeneration
Pascoe, Amy L.
Johnston, Amelia J.
Murphy, Robyn M.
[J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2020, 77 (17) : 3369 - 3381
[3] The TWEAK-Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice
Mittal, Ashwani
Bhatnagar, Shephali
Kumar, Akhilesh
Lach-Trifilieff, Estelle
Wauters, Sandrine
Li, Hong
Makonchuk, Denys Y.
Glass, David J.
Kumar, Ashok
[J]. JOURNAL OF CELL BIOLOGY, 2010, 188 (06): : 833 - 849
[4] TWEAK-Fn14 Pathway Markers: Time Course After Resistance or Run Exercise in Human Skeletal Muscle
Raue, Ulrika
Jemiolo, Bozena
Yang, Yifan
Trappe, Scott
[J]. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2013, 45 (05): : 303 - 303
[5] The TWEAK-Fn14 System: Breaking the Silence of Cytokine-Induced Skeletal Muscle Wasting
Bhatnagar, S.
Kumar, A.
[J]. CURRENT MOLECULAR MEDICINE, 2012, 12 (01) : 3 - 13
[6] The TWEAK-Fn14 dyad is involved in age-associated pathological changes in skeletal muscle
Tajrishi, Marjan M.
Sato, Shuichi
Shin, Jonghyun
Zheng, Timothy S.
Burkly, Linda C.
Kumar, Ashok
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 446 (04) : 1219 - 1224
[7] TWEAK-Fn14 as a common pathway in the heart and the kidneys in cardiorenal syndrome
Poveda, Jonay
Vazquez-Sanchez, Sara
Sanz, Ana B.
Ortiz, Alberto
Ruilope, Luis M.
Ruiz-Hurtado, Gema
[J]. JOURNAL OF PATHOLOGY, 2021, 254 (01): : 5 - 19
[8] The Potential of Therapeutic Targeting of the TWEAK-Fn14 pathway in Atopic Dermatitis
Gupta, Rinkesh Kumar
Fung, Kai
Figueroa, Daniela
Miller, Jacqueline
Ay, Ferhat
Croft, Michael
[J]. JOURNAL OF IMMUNOLOGY, 2023, 210 (01):
[9] Regulatory circuitry of TWEAK-Fn14 system and PGC-1α in skeletal muscle atrophy program
Hindi, Sajedah M.
Mishra, Vivek
Bhatnagar, Shephali
Tajrishi, Marjan M.
Ogura, Yuji
Yan, Zhen
Burkly, Linda C.
Zheng, Timothy S.
Kumar, Ashok
[J]. FASEB JOURNAL, 2014, 28 (03): : 1398 - 1411
[10] TWEAK-Fn14 as a mediator of acute kidney injury
Weinberg, Joel M.
[J]. KIDNEY INTERNATIONAL, 2011, 79 (02) : 151 - 153

← 1 2 3 4 5 →