STAT6 inhibits T-bet-independent Th1 cell differentiation

被引：12
|
作者：
Tamachi, Tomohiro [2 ]
Takatori, Hiroaki [2 ]
Fujiwara, Michio [2 ]
Hirose, Koichi [2 ]
Maezawa, Yuko [2 ]
Kagami, Shin-ichiro [1 ,2 ]
Suto, Akira [1 ,2 ]
Watanabe, Norihiko [2 ]
Iwamoto, Itsuo [3 ]
Nakajima, Hiroshi [1 ,2 ]
机构：
[1] Chiba Univ, Grad Sch Med, Dept Mol Genet, Chiba 2608670, Japan
[2] Chiba Univ, Dept Allergy & Clin Immunol, Chiba 2608670, Japan
[3] Asahi Gen Hosp, Res Ctr Allergy & Clin Immunol, Chiba, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 382卷 / 04期
关键词：
Th1/Th2; Cells; T-bet; STAT6; STAT4; IFN-GAMMA PRODUCTION; TRANSCRIPTION; EXPRESSION; RESPONSES; EOMESODERMIN; COMMITMENT; CD4;
D O I：
10.1016/j.bbrc.2009.03.101
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
STAT6 plays critical roles in Th2 cell differentiation, whereas STAT4 and T-bet are important for Th1 cell differentiation. However, it is still largely unknown about the cross talk of these transcription factors during Th1/Th2 cell differentiation. To further address the regulatory mechanisms underlying Th1/Th2 cell differentiation, we generated the mice lacking both STAT6 and T-bet (STAT(-/-) T-bet(-/-) mice). Importantly, although Th2 cell differentiation was severely and similarly decreased in STAT6(-/-) T-bet(-/-) mice and STAT6(-/-) mice. Th1 cell differentiation was rescued in part in STAT6(-/-) T-bet(-/-) mice as compared with that in T-bet(-/-). While no significant difference was observed in the expression of IL-12R beta 2 and STAT4 between STAT6(-/-) T-bet(-/-) CD4(+) T cells and T-bet(-/-) CD4(+) T cells, IL-12-induced STAT4 phosphorylation was increased in STAT6(-/-) T-bet(-/-) CD4(+) T cells as compared with that in T-bet(-/-) CD4(+) T cells. These results indicate that STAT6 inhibits T-bet-independent Th1 cell differentiation by suppressing IL-12-STAT4 signaling. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：751 / 755
页数：5
相关论文
共 50 条
  • [1] T-bet-independent TH1 immunity to Toxoplasma gondii drives intestinal immunopathological response
    Lopez-Yglesias, Americo H.
    Burger, Elise
    Yarovinsky, Felix
    JOURNAL OF IMMUNOLOGY, 2016, 196
  • [2] T-bet-independent Th1 response induces intestinal immunopathology during Toxoplasma gondii infection
    Lopez-Yglesias, Americo H.
    Burger, Elise
    Araujo, Alessandra
    Martin, Andrew T.
    Yarovinsky, Felix
    MUCOSAL IMMUNOLOGY, 2018, 11 (03) : 921 - 931
  • [3] IFN-[gamma] inhibits STAT6 phosphorylation in differentiated Th1 cells
    Xin, JP
    Zhang, YK
    Huang, H
    FASEB JOURNAL, 2002, 16 (04): : A700 - A700
  • [4] Dexmedetomidine Directs T Helper Cells toward Th1 Cell Differentiation via the STAT1-T-Bet Pathway
    Lei, Daoyun
    Liu, Li
    Xie, Songhui
    Ji, Haiyan
    Guo, Yanxing
    Ma, Tieliang
    Han, Chao
    BIOMED RESEARCH INTERNATIONAL, 2021, 2021
  • [5] Stat1, stat6 and th1 & th2 cytokines in periodontal disease.
    Lappin, DF
    Kinane, DF
    JOURNAL OF DENTAL RESEARCH, 2003, 82 : 511 - 511
  • [6] Differential expression of chemokines in T helper type 1 (Th1) and Th2 cells is dependent on Stat6 but not Stat4
    Zhang, SM
    Lukacs, NW
    Lawless, VA
    Kunkel, SL
    Kaplan, MH
    FASEB JOURNAL, 2000, 14 (06): : A1092 - A1092
  • [7] TGF-β1 inhibits Th1 development and T helper cell expression of T-bet and Hlx
    Lin, JT
    Robinson, RT
    Gorham, JD
    FASEB JOURNAL, 2003, 17 (07): : C130 - C130
  • [8] Stat4-dependent, T-bet-independent regulation of IL-10 in NK cells
    Grant, L. R.
    Yao, Z-J
    Hedrich, C. M.
    Wang, F.
    Moorthy, A.
    Wilson, K.
    Ranatunga, D.
    Bream, J. H.
    GENES AND IMMUNITY, 2008, 9 (04) : 316 - 327
  • [9] Oral feeding of Lactobacillus bulgaricus N45.10 inhibits the lung inflammation and airway remodeling in murine allergic asthma: Relevance to the Th1/Th2 cytokines and STAT6/T-bet
    Anatriello, E.
    Cunha, M.
    Nogueira, J.
    Carvalho, J. L.
    Sa, A. K.
    Miranda, M.
    Castro-Faria-Neto, H.
    Keller, A. C.
    Aimbire, F.
    CELLULAR IMMUNOLOGY, 2019, 341
  • [10] Interferon-[gamma] suppresses STAT6 phosphorylation in Th1 cells by inhibiting the recruitment of STAT6 to the IL-4 receptor
    Huang, H
    Huang, Z
    Xin, JP
    Coleman, J
    FASEB JOURNAL, 2004, 18 (04): : A57 - A57
12345