A facile access to the 1,5-dihydro- and 1,3,4,5-tetrahydro-benzo[b]azepin-2-one ring systems via a new ring enlargement

被引：0

作者：

Pauvert, M ^{[1
]}

Dupont, V ^{[1
]}

Guingant, A ^{[1
]}

机构：

[1] Fac Sci & Tech, Synth Organ Lab, F-44322 Nantes 03, France

来源：

SYNLETT | 2002年 / 08期

关键词：

quinolinium salt; silver nitrate; 1,5-dihydro-benzo[b]azepin-2-one; 1,3,4,5-tetrahydro-benzo[b] azepin-2-one; ring enlargement;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of a 1,5-dihydro-benzo[b]azepin-2-one is reported. The key reaction is a silver nitrate-induced rearrangement of N-benzyl quinolinium bromide. Its reduction leads to the 1,3,4,5-tetrahydro-benzo[b] azepin-2-one ring system found in several pharmacological important compounds.

引用

页码：1350 / 1352

页数：3

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