Carnosine and related compounds protect against the hydrogen peroxide-mediated cytochrome c modification

被引：0
|
作者：
Kang, Jung Hoon [1 ]
机构：
[1] Cheongju Univ, Dept Genet Engn, Cheongju 360764, South Korea
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2006年 / 27卷 / 05期
关键词：
cytochrome c; oligomerization; free radical scavenger; carnosine;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Carnosine, homocarnosine and anserine might act as anti-oxidants and free radical scavengers in vivo. In the present study, the protective effects of carnosine and related compounds on the H2O2-mediated cytochrome c modification were studied. Carnosine, homocarnosine and anserine significantly inhibited the oligomerization of cytchrome c induced by H2O2. All three compounds also inhibited the formation of carbonyl compound and dityrosine during the incubation of cytochrome c with H2O2. These compounds effectively inhibited the peroxidase activity in the cytchrome c treated with H2O2. The results suggested that carnosine, homocarnosine, and anserine might protect cytochrome c against H2O2-mediated oxidative damage through a free radical scavenging.
引用
收藏
页码：663 / 666
页数：4
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