No association between inhaled corticosteroids and whole body DXA in postmenopausal women

被引:3
|
作者
Elmstahl, Solve
Ekstrom, Henrik
Johnell, Olof
de Verdier, Maria Gerhardsson
Norjavaara, Ensio
机构
[1] Malmo Univ Hosp, Div Geriat Med, Dept Hlth Sci, SE-20502 Malmo, Sweden
[2] Lund Univ, Dept Orthopaed, Malmo, Sweden
[3] AstrZeneca R&D, Lund, Sweden
[4] Univ Lund Hosp, Dept Resp Med, Lund, Sweden
[5] AstraZeneca R&D, Molndal, Sweden
[6] Univ Gothenburg, Paediat Growth Res Ctr, Gothenburg, Sweden
关键词
bone mineral density; cohort study; inhaled corticosteroids; postmenopausal;
D O I
10.1002/pds.1255
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Purpose Postmenopausal women treated with corticosteroids are regarded as a high-risk group due to the effect of both natural bone loss and possible adverse effects of treatment with inhaled corticosteroids (IC). Objective To compare bone mineral density (BMD) in postmenopausal women exposed only to IC (IC group, n = 106) with that of BMD in women not exposed to corticosteroids (n = 124) and women exposed to oral and/or intra-articular injections in addition to inhaled corticosteroids (OC group, n = 3 1). The women were recruited from a population-based prospective cohort study. Methods Dual X-ray absorptiometry (DXA) technique was used to measure BMD in whole body, spine, pelvis and lower extremities. A health questionnaire and an interview about past and present medication use were used. Results The mean duration and dose of IC were 9.5 +/- 4.5 years and 615 mu g daily. Whole body BMD did not significantly differ between the IC group (1.103 g/cm(2)) and the unexposed group (1.087 g/cm(2)). Within the IC group, BMD stratified for cumulative dose of IC, duration or current dose above or below 800 jig did not differ. Z-score BMD for tertiles did not differ when comparing the IC and OC groups. Conclusion No difference in BMD was noted between postmenopausal women exposed to inhaled corticosteroids and unexposed controls nor was there any dose response relationship between inhaled corticosteroid therapy and BMD. Copyright (c) 2006 John Wiley & Sons, Ltd.
引用
收藏
页码:527 / 535
页数:9
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