Novel self-assembled lithocholic acid nanoparticles for drug delivery in cancer

被引：16
|
作者：
Patil, Sumersing [1 ,2 ]
Patil, Sohan [1 ]
Gawali, Suhas [1 ]
Shende, Shrikant [1 ]
Jadhav, Shraddha [1 ]
Basu, Sudipta [1 ]
机构：
[1] Indian Inst Sci Educ & Res IISER Pune, Dept Chem, Pune 411021, Maharashtra, India
[2] Univ Pune, Inst Bioinformat & Biotechnol, Pune 411007, Maharashtra, India
来源：
RSC ADVANCES | 2013年 / 3卷 / 43期
关键词：
DOXORUBICIN-INDUCED CARDIOMYOPATHY; BILE-ACIDS; PHASE-I; NANOTECHNOLOGY; PACLITAXEL; PATHWAY; CELLS; CHEMOTHERAPY; CHEMISTRY; EFFICACY;
D O I：
10.1039/c3ra42994f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Novel versatile self-assembled nanoparticles were developed from biocompatible, biodegradable lithocholic acid derivatives. These nanoparticles can incorporate different cytotoxic drugs (paclitaxel and doxorubicin) and PI3K signalling inhibitor (PI103). Drugs were released from the nanoparticles in a slow, sustained manner at acidic pH. The drug loaded nanoparticles were internalized through lysosomal compartments and induced cell death in HeLa cervical cancer cells.
引用
收藏
页码：19760 / 19764
页数：5
相关论文
共 50 条
  • [1] Self-assembled cyclodextrin nanoparticles and drug delivery
    Thorsteinn Loftsson
    Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2014, 80 : 1 - 7
  • [2] Self-assembled cyclodextrin nanoparticles and drug delivery
    Loftsson, Thorsteinn
    JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2014, 80 (1-2) : 1 - 7
  • [3] Self-Assembled Hydrogel Nanoparticles for Drug Delivery Applications
    Goncalves, Catarina
    Pereira, Paula
    Gama, Miguel
    MATERIALS, 2010, 3 (02): : 1420 - 1460
  • [4] Recent Advances in Self-Assembled Nanoparticles for Drug Delivery
    Varma, Lanke Tejesh
    Singh, Nidhi
    Gorain, Bapi
    Choudhury, Hira
    Tambuwala, Murtaza M.
    Kesharwani, Prashant
    Shukla, Rahul
    CURRENT DRUG DELIVERY, 2020, 17 (04) : 279 - 291
  • [5] Chitosan Based Self-Assembled Nanoparticles in Drug Delivery
    Quinones, Javier Perez
    Peniche, Hazel
    Peniche, Carlos
    POLYMERS, 2018, 10 (03)
  • [6] Novel biocompatible phosphorylcholine-based self-assembled nanoparticles for drug delivery
    Salvage, JP
    Rose, SF
    Phillips, GJ
    Hanlon, GW
    Lloyd, AW
    Ma, IY
    Armes, SP
    Billingham, NC
    Lewis, AL
    JOURNAL OF CONTROLLED RELEASE, 2005, 104 (02) : 259 - 270
  • [7] Novel Multifunctional Biocompatible Gelatin-Oleic Acid Conjugate: Self-Assembled Nanoparticles for Drug Delivery
    Phuong Ha-Lien Tran
    Thao Truong-Dinh Tran
    Toi Van Vo
    Chau Le-Ngoc Vo
    Lee, Beom-Jin
    JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2013, 9 (08) : 1416 - 1431
  • [8] Preparation of Self-assembled Nanoparticles of Stearic Acid Modified Pullulan Derivatives and Their Application as Novel Carriers of Drug Delivery
    Wang Jingyun
    Song Dandan
    Bao Yongming
    ACTA CHIMICA SINICA, 2012, 70 (10) : 1193 - 1200
  • [9] Peptide Self-Assembled Nanocarriers for Cancer Drug Delivery
    Kumar, Vijay Bhooshan
    Ozguney, Busra
    Vlachou, Anastasia
    Chen, Yu
    Gazit, Ehud
    Tamamis, Phanourios
    JOURNAL OF PHYSICAL CHEMISTRY B, 2023, 127 (09): : 1857 - 1871
  • [10] Self-assembled protein-based nanoparticles for drug delivery
    Kim, Wookhyun
    Chaikof, Elliot L.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 239
12345