Plasma exchange in severe spinal attacks associated with neuromyelitis optica spectrum disorder

被引:141
|
作者
Bonnan, M. [1 ]
Valentino, R.
Olindo, S. [1 ]
Mehdaoui, H.
Smadja, D. [1 ]
Cabre, P. [1 ]
机构
[1] Hop Zobda Quitman, Serv Neurol, Fort De France 97261, Martinique, France
关键词
neuromyelitis optica; NMo-IgG; plasma exchange; transverse myelitis; FRENCH-WEST-INDIES; MULTIPLE-SCLEROSIS; TRANSVERSE MYELITIS; DEVICS-SYNDROME; WATER CHANNEL; NMO-IGG; DISEASE; CYCLOPHOSPHAMIDE; PLASMAPHERESIS; EXPERIENCE;
D O I
10.1177/1352458508100837
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background Plasma exchange (PE) is increasingly undertaken in diseases involving humoral factors and is proven to be beneficial in acute demyelinating diseases. Spinal attacks in relapsing neuromyelitis optica (NMO) and in extensive transverse myelitis (ETM) - a truncated form of NMO with spinal involvement - are usually devastating. Objective We retrospectively studied the outcome of PE-treated versus steroid-only treated spinal attacks in relapsing NMO and ETM. Methods We included 96 severe spinal attacks in 43 Afro-Caribbean patients. PE was given as an add-on therapy in 29 attacks. Expanded disability status score (EDSS) was obtained before attack, during the acute and residual stage. We defined the Delta EDSS as the rise from basal to residual EDSS. Results The Delta EDSS was found to be lower in the PE-treated group (1.2 +/- 1.6 vs 2.6 +/- 2.3; P < 0.01). A low basal impairment is associated with a better outcome. Improvement was obtained in both NMO-IgG negative and positive NMO attacks. Minor adverse events manifested in seven PE sessions (24%). Conclusion PE appears to be a safe add-on therapy that may be employed early in severe spinal attacks in the NMO spectrum disorders in order to maximize improvement rate. PE efficiency is independent of NMO-IgG positivity. Multiple Sclerosis 2009; 15: 487-492. http://msj.sagepub.com
引用
收藏
页码:487 / 492
页数:6
相关论文
共 50 条
  • [1] Plasma Exchange in Severe Attacks of Neuromyelitis Optica
    Bonnan, Mickael
    Cabre, Philippe
    [J]. MULTIPLE SCLEROSIS INTERNATIONAL, 2012, 2012
  • [2] Plasma exchange and immunoadsorption for neuromyelitis optica spectrum disorder attacks.
    Kleiter, I.
    Gahlen, A.
    Borisow, N.
    Wernecke, K. -D.
    Trebst, C.
    [J]. MULTIPLE SCLEROSIS JOURNAL, 2016, 22 : 23 - 24
  • [3] Plasma Exchange In Acute Relapses of Neuromyelitis Optica Spectrum Disorder
    Le, Wee
    Tan, K.
    [J]. MULTIPLE SCLEROSIS JOURNAL, 2013, 19 (05) : 685 - 685
  • [4] Plasma exchange for acute optic neuritis in neuromyelitis optica or neuromyelitis optica spectrum disorder: a systematic review
    Naphattalung, Yachinee
    Chuenkongkaew, Wanicha Leetiratanai
    Chirapapaisan, Niphon
    Laowanapiban, Poramaet
    Sawangkul, Supattra
    [J]. ANNALS OF MEDICINE, 2023, 55 (01)
  • [5] Therapeutic plasma exchange for optic neuritis attacks in patients with neuromyelitis optica spectrum disorders
    Gonzalez, Camilo
    Vargas, Diana
    Contreras, Kateir
    Garcia, Paola
    Rodriguez, Patricia
    Zarco, Luis
    Navas, Carlos
    [J]. THERAPEUTIC APHERESIS AND DIALYSIS, 2022, 26 (06) : 1274 - 1280
  • [6] Plasma Exchange as a First Line Therapy in Acute Attacks of Neuromyelitis Optica Spectrum Disorders
    Kumawat, B. L.
    Choudhary, Reenu
    Sharma, C. M.
    Jain, Deepak
    Hiremath, Ashwini
    [J]. ANNALS OF INDIAN ACADEMY OF NEUROLOGY, 2019, 22 (04) : 389 - 394
  • [7] Beneficial effect of plasma exchange in acute attack of neuromyelitis optica spectrum disorder
    Siritho, S.
    Srisupa-Olan, T.
    Sathukitchai, C.
    Prayoonwiwat, N.
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2017, 381 : 1062 - 1063
  • [8] Predictive value of conventional MRI parameters in first spinal attacks of neuromyelitis optica spectrum disorder
    Bonnan, M.
    Debeugny, S.
    Mejdoubi, M.
    Cabre, P.
    [J]. EUROPEAN JOURNAL OF NEUROLOGY, 2019, 26 : 158 - 158
  • [9] Predictive value of conventional MRI parameters in first spinal attacks of neuromyelitis optica spectrum disorder
    Bonnan, Mickael
    Debeugny, Stephane
    Mejdoubi, Mehdi
    Cabre, Philippe
    [J]. MULTIPLE SCLEROSIS JOURNAL, 2020, 26 (04) : 468 - 475
  • [10] Comparison of efficacy of plasma exchange versus intravenous immunoglobulin as an add-on therapy in acute attacks of neuromyelitis optica spectrum disorder
    Siwach, Garima
    Hans, Rekha
    Takkar, Aastha
    Ahuja, Chirag Kamal
    Lamba, Divjot Singh
    Lal, Vivek
    Sharma, Ratti Ram
    [J]. JOURNAL OF CLINICAL APHERESIS, 2024, 39 (03)