Epithelial Mesenchymal Transition Confers Properties of Stem Cells on Cancer Cells

被引：0
|
作者：
Yu Shuai-Shuai [1 ]
Ma Xiao-Juan [1 ]
Lin Bi-Hua [2 ]
Li Ji-Xia [2 ]
Zhou Ke-Yuan [1 ,2 ]
机构：
[1] Guangdong Med Coll, Guangdong Key Lab Med Mol Diagnost, Dongguan 523808, Peoples R China
[2] Guangdong Med Coll, Inst Biochem & Mol Biol, Dongguan 523808, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2014年 / 41卷 / 07期
基金：
中国国家自然科学基金;
关键词：
EMT; CSC; sternness; drug resistance; BREAST-CANCER; SELF-RENEWAL; TGF-BETA; PHENOTYPE; HEDGEHOG; PROMOTES; EMT; METASTASIS; SNAIL; DIFFERENTIATION;
D O I：
10.3724/SP.J.1206.2013.00359
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The epithelial mesenchymal transition(EMT)confers mesenchymal properties, migration and invasion on epithelial cells which normally is polarized and interacts with basement membrane via its basal surface. Cancer stem cell is a small subset of stem-like cells which have the capacity for self-renewal and asymmetric cell division. They play an important role in cancer initiation and progression. In rencent years, some researches reveal that EMT, which is closely related tumor metastasis, can generate tumour cells with propreties of stem cells. We review here recent observations correlated with the mechanism of it and its significance to clinical therapy.
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收藏
页码：632 / 639
页数：8
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