8-Hydroxy-2'-deoxyguanosine (8-OHdG) as a possible marker of arsenic poisoning: a clinical case study on the relationship between concentrations of 8-OHdG and each arsenic compound in urine of an acute promyelocytic leukemia patient being treated with arsenic trioxide

被引：8

作者：

Fujihara, Junko ^{[1
]}

Agusa, Tetsuro ^{[1
]}

Tanaka, Junko ^{[2
]}

Fujii, Yoshimi ^{[1
]}

Moritani, Tamami ^{[1
]}

Hasegawa, Masanori ^{[3
]}

Iwata, Hisato ^{[4
]}

Tanabe, Shinsuke ^{[4
]}

Takeshita, Haruo ^{[1
]}

机构：

[1] Shimane Univ, Fac Med, Dept Legal Med, Izumo, Shimane 6938501, Japan

[2] Shimane Univ, Fac Med, Dept Internal Med, Izumo, Shimane 6938501, Japan

[3] Shimane Prefectural Police Headquarters, Criminal Invest Lab, Matsue, Shimane, Japan

[4] Ehime Univ, CMES, Matsuyama, Ehime, Japan

来源：

FORENSIC TOXICOLOGY | 2009年 / 27卷 / 01期

基金：

日本学术振兴会;

关键词：

Arsenic trioxide; 8-OHdG; Dimethylarsinic acid; Monomethylarsonic acid; Promyelocytic leukemia; DNA-DAMAGE; IN-VITRO; METABOLITES; SPECIATION;

D O I：

10.1007/s11419-008-0062-x

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Arsenic trioxide (ATO) is an effective therapeutic agent for acute promyelocytic leukemia (APL). In the present study, the concentrations of 8-hydroxy-2'-deoxyguanosine (8-OHdG) and arsenic compounds [(dimethylarsinic acid (DMA), monomethylarsonic acid (MMA), As(V), and As(III)] in urine of an APL patient were determined during ATO treatment. The concentrations of 8-OHdG, DMA, and MMA were increased, especially during the fi rst consolidation therapy. Signifi cant positive correlations were observed between concentrations of 8-OHdG and DMA, between concentrations of 8-OHdG and MMA, and between concentrations of 8-OHdG and the sum of arsenic compounds. The present study supports the idea that urinary 8-OHdG can be a marker for arsenic poisoning, when it is detected together with DMA and MMA. In addition, this study is the fi rst to show the relationship between 8-OHdG and levels of arsenic compounds in urine of an APL patient being treated with ATO.

引用

页码：41 / 44

页数：4

共 6 条

[1] 8-Hydroxy-2′-deoxyguanosine (8-OHdG) as a possible marker of arsenic poisoning: a clinical case study on the relationship between concentrations of 8-OHdG and each arsenic compound in urine of an acute promyelocytic leukemia patient being treated with arsenic trioxide
Junko Fujihara
Tetsuro Agusa
Junko Tanaka
Yoshimi Fujii
Tamami Moritani
Masanori Hasegawa
Hisato Iwata
Shinsuke Tanabe
Haruo Takeshita
Forensic Toxicology, 2009, 27 : 41 - 44
[2] Correlation of urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, and clinical features of hematological disorders:: a pilot study
Honda, M
Yamada, Y
Tomonaga, M
Ichinose, H
Kamihira, S
LEUKEMIA RESEARCH, 2000, 24 (06) : 461 - 468
[3] Rapid extraction and analysis of oxidative stress and DNA damage biomarker 8-hydroxy-2′-deoxyguanosine (8-OHdG) in urine: Application to a study with pregnant women
Blahova, Lucie
Janos, Tomas
Mustieles, Vicente
Rodriguez-Carrillo, Andrea
Fernandez, Mariana F.
Blaha, Ludek
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, 2023, 250
[4] 8-Hydroxy-2'-deoxyguanosine and arsenic compounds in urine and serum of a 4-year-old child suffering from acute promyelocytic leukemia during treatment with arsenic trioxide
Fujihara, Junko
Hasegawa, Masanori
Kanai, Rie
Agusa, Tetsuro
Iwata, Hisato
Tanabe, Shinsuke
Yasuda, Toshihiro
Yamaguchi, Seiji
Takeshita, Haruo
FORENSIC TOXICOLOGY, 2011, 29 (01) : 65 - 68
[5] 8-Hydroxy-2′-deoxyguanosine and arsenic compounds in urine and serum of a 4-year-old child suffering from acute promyelocytic leukemia during treatment with arsenic trioxide
Junko Fujihara
Masanori Hasegawa
Rie Kanai
Tetsuro Agusa
Hisato Iwata
Shinsuke Tanabe
Toshihiro Yasuda
Seiji Yamaguchi
Haruo Takeshita
Forensic Toxicology, 2011, 29 : 65 - 68
[6] Comparative study of the formation of oxidative damage marker 8-hydroxy-2′-deoxyguanosine (8-OHdG) adduct from the nucleoside 2′-deoxyguanosine by transition metals and suspensions of particulate matter in relation to metal content and redox reactivity
Valavanidis, A
Vlahoyianni, T
Fiotakis, K
FREE RADICAL RESEARCH, 2005, 39 (10) : 1071 - 1081

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