The Synthetic and Biological Attributes of Pyrazole Derivatives: A Review

被引：48
|
作者：
Dwivedi, Jaya [1 ]
Sharma, Swapnil [2 ]
Jain, Sonika [1 ]
Singh, Aarti [1 ]
机构：
[1] Banasthali Univ, Dept Chem, Banasthali 304022, Rajasthan, India
[2] Banasthali Univ, Dept Pharm, Banasthali 304022, Rajasthan, India
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2018年 / 18卷 / 11期
关键词：
Combinatorial chemistry; medicinal chemistry; pharmacological activity; pharmacophore; pyrazole; QSAR; ONE-POT SYNTHESIS; REGIOSELECTIVE SYNTHESIS; 1,3,5-TRISUBSTITUTED PYRAZOLES; ANTICONVULSANT ACTIVITY; INHIBITORY-ACTIVITY; CHANNEL INHIBITORS; KINASE INHIBITORS; DIAZO-COMPOUNDS; DESIGN; DISCOVERY;
D O I：
10.2174/1389557517666170927160919
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Pyrazole nucleus is a unique structural scaffold which acts as an interesting template for combinatorial as well as medicinal chemistry. This review presents a detailed overview on the synthesis, QSAR and pharmacological applications of pyrazole. In addition, it covers most recent reports on structural modifications on pyrazole illustrating vital structural activity relationship.
引用
收藏
页码：918 / 947
页数：30
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