Association of renal function with retinal vessel density in patients with type 2 diabetes by using swept-source optical coherence tomographic angiography

被引:25
|
作者
Wang, Wei [1 ]
He, Miao [1 ]
Gong, Xia [1 ]
Wang, Lanhua [2 ]
Meng, Jie [1 ]
Li, Yuting [1 ]
Xiong, Kun [1 ]
Li, Wangting [3 ]
Huang, Wenyong [2 ]
机构
[1] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, Guangzhou, Guangdong, Peoples R China
[2] Zhongshan Ophthalm Ctr, Dept Prevent Ophthalmol, Guangzhou 510060, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
CHRONIC KIDNEY-DISEASE; EYE DISEASES; RETINOPATHY; RISK;
D O I
10.1136/bjophthalmol-2019-315450
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Aims To investigate the relationship between retinal vessel density and renal function in patients with diabetes mellitus (DM) using non-invasive optical coherence tomographic angiography (OCTA). Methods This prospective cross-sectional study recruited ocular-treatment-naive patients with DM registered in the community of Guangzhou, China. The retinal vessel density of the superficial capillary plexus in the macula was obtained by using swept-source OCTA imaging. The Xiangya equation was used to calculate the estimated glomerular filtrate rate (eGFR). Participants were divided into the following groups by eGFR: no chronic kidney disease (non-CKD), mild CKD and moderate-to-severe CKD (MS-CKD). Results A total of 874 patients with DM (874 eyes), with a mean age of 64.8 +/- 7.1 years, were included in the final analysis. The vessel density was significantly lower in patients with CKD than in non-CKD patients in a dose-response pattern, with a parafoveal vessel density of 49.1%+/- 2.1% in non-CKD, 48.4%+/- 1.9% in mild CKD and 47.2%+/- 1.7% in MS-CKD (p<0.001). The sparser retinal capillaries were related to lower eGFR (beta=0.037; 95% CI 0.025 to 0.049; p<0.001) and higher microalbuminuria (beta = -0.023; 95% CI -0.039 to -0.008; p=0.002). The eGRF was independently associated with parafoveal vessel density (beta=0.029; 95% CI 0.016 to 0.042; p<0.001), even after adjusting for other factors. Conclusion Retinal vessel density decreased with renal function impairment, underlining the potential value of OCTA to detect early microvascular damage in the kidney in patients with diabetes.
引用
收藏
页码:1768 / 1773
页数:6
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