Late-Onset Alzheimer Disease

被引：35

作者：

Pierce, Aimee L. ^{[1
,2
]}

Bullain, Szofia S. ^{[3
,4
]}

Kawas, Claudia H. ^{[5
,6
,7
,8
]}

机构：

[1] Univ Calif Irvine, Dept Neurol, 1100 Med Plaza Dr, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, 1100 Med Plaza Dr, Irvine, CA 92697 USA

[3] Univ Calif Irvine, Dept Neurol, 1515 Hewitt Hall, Irvine, CA 92697 USA

[4] Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, 1515 Hewitt Hall, Irvine, CA 92697 USA

[5] Univ Calif Irvine, Dept Neurol, 1121 Gillespie, Irvine, CA 92697 USA

[6] Univ Calif Irvine, Dept Neurobiol & Behav, 1121 Gillespie, Irvine, CA 92697 USA

[7] Univ Calif Irvine, Dept Epidemiol, 1121 Gillespie, Irvine, CA 92697 USA

[8] Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, 1121 Gillespie, Irvine, CA 92697 USA

来源：

NEUROLOGIC CLINICS | 2017年 / 35卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Late-onset; Alzheimer disease; Dementia; Oldest-old; Pathology; OLDEST-OLD; DEMENTIA; ASSOCIATION; AGE; PREDICTORS; EFFICACY; COMMON; RISK;

D O I：

10.1016/j.ncl.2017.01.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The oldest-old represent the fastest growing segment of society, and the risk of developing dementia continues to increase with advancing age into the 9th and 10th decades of life. The most common form of dementia in the oldest-old is Alzheimer disease (AD), although there are often mixed pathologies contributing to dementia in addition to amyloid plaques and neurofibrillary tangles. Diagnosing AD in the oldest-old is challenging due to cognitive and physical changes associated with aging. Treatment remains supportive, with current approved medications able to provide modest symptomatic benefit but unable to slow the progression of disease.

引用

页码：283 / +

页数：13

共 50 条

[1] Genetic analyses of late-onset Alzheimer disease
Tanzi, R
NEUROBIOLOGY OF AGING, 2004, 25 : S25 - S25
[2] The genetics of late-onset Alzheimer's disease
Myers, AJ
Goate, AM
CURRENT OPINION IN NEUROLOGY, 2001, 14 (04) : 433 - 440
[3] Cannabinoids in Late-Onset Alzheimer's Disease
Ahmed, A. I. A.
van der Marck, M. A.
van den Elsen, G. A. H.
Rikkert, M. G. M. Olde
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2015, 97 (06) : 597 - 606
[4] Identification of novel genes in late-onset Alzheimer disease
Pericak-Vance, MA
Duke, JB
NEUROBIOLOGY OF AGING, 2002, 23 (01) : S11 - S11
[5] Late-onset autosomal dominant Alzheimer's disease
Hancock, P.
Larner, A. J.
EUROPEAN JOURNAL OF NEUROLOGY, 2007, 14 : 187 - 188
[6] Deciphering the mechanism underlying late-onset Alzheimer disease
Dimitrije Krstic
Irene Knuesel
Nature Reviews Neurology, 2013, 9 : 25 - 34
[7] LINKING Aβ AND TAU IN LATE-ONSET ALZHEIMER'S DISEASE
Small, S. A.
GERONTOLOGIST, 2009, 49 : 143 - 143
[8] Deciphering the mechanism underlying late-onset Alzheimer disease
Krstic, Dimitrije
Knuesel, Irene
NATURE REVIEWS NEUROLOGY, 2013, 9 (01) : 25 - 34
[9] Etiology and Pathogenesis of Late-Onset Alzheimer's Disease
Balin, Brian J.
Hudson, Alan P.
CURRENT ALLERGY AND ASTHMA REPORTS, 2014, 14 (03)
[10] Molecular genetics of late-onset Alzheimer's disease
Kamboh, MI
ANNALS OF HUMAN GENETICS, 2004, 68 : 381 - 404

← 1 2 3 4 5 →