CREB function is required for normal thymic cellularity and post-irradiation recovery

被引:18
|
作者
Baumann, S
Kyewski, B
Bleckmann, SC
Greiner, E
Rudolph, D
Schmid, W
Ramsay, RG
Krammer, PH
Schütz, G
Mantamadiotis, T
机构
[1] Peter MacCallum Canc Ctr, Differentiat & Transcript Lab, Melbourne, Vic 8006, Australia
[2] Deutsch Krebsforschungszentrum, D-6900 Heidelberg, Germany
关键词
rodent; T lymphocytes; transcription factors; transgenic; knockout; thymus;
D O I
10.1002/eji.200324826
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Recent generation of genetically modified Creb1 mutant mice has revealed an important role for CREB (CAMP responsive element binding protein) and the related proteins CREM (CAMP responsive element modulator) and ATF1 (activating transcription factor 1) in cell survival, in agreement with previous studies using overexpression of dominant-negative CREB (dnCREB). CREB and ATF1 are abundantly expressed in T cells and are rapidly activated by phosphorylation when T cells are stimulated through the T cell antigen receptor. We show that T cell-specific loss of CREB in mice, in combination with the loss of ATF1, results in reduced thymic cellularity and delayed thymic recovery following sublethal irradiation but no changes in T cell development or activation. These data show that loss of CREB function has specific effects on thymic T lymphocyte proliferation and homeostasis in vivo.
引用
收藏
页码:1961 / 1971
页数:11
相关论文
共 50 条
  • [1] A MODEL FOR POST-IRRADIATION ERYTHROPOIETIC RECOVERY
    OKUNEWIC.JP
    KRETCHMA.AL
    RADIATION RESEARCH, 1967, 31 (03) : 605 - &
  • [2] POST-IRRADIATION RECOVERY OF ESCHERICHIA COLI
    LEE, JS
    SINNHUBER, RO
    NATURE, 1965, 207 (5002) : 1212 - +
  • [3] POST-IRRADIATION ERYTHROPOIETIC RECOVERY IN SPLENECTOMIZED MICE
    AGGIO, MC
    SCANDINAVIAN JOURNAL OF HAEMATOLOGY, 1978, 21 (02): : 163 - 166
  • [4] POST-IRRADIATION ANAEROBIOSIS AND RECOVERY OF ASCARIS EGGS
    PAHL, G
    BACHOFER, CS
    RADIATION RESEARCH, 1954, 1 (06) : 555 - 556
  • [5] Post-irradiation recovery of growth plate function is driven by expansions of regenerative clones.
    Horton, JA
    Margulies, BS
    Strauss, JA
    Damron, TA
    Spadaro, JA
    JOURNAL OF BONE AND MINERAL RESEARCH, 2004, 19 : S350 - S351
  • [6] Rat models of post-irradiation recovery of spermatogenesis: interstrain differences
    Abuelhija, M.
    Weng, C. C.
    Shetty, G.
    Meistrich, M. L.
    ANDROLOGY, 2013, 1 (02) : 206 - 215
  • [7] Repeatability of irradiation damage and of recovery by post-irradiation annealing of EUROFER base steels
    Schneider, H. -C.
    Petersen, C.
    Povstyanko, A. V.
    Fedoseev, A. E.
    Makarov, O.
    FUSION ENGINEERING AND DESIGN, 2017, 124 : 1019 - 1023
  • [8] ENHANCED POST-IRRADIATION RECOVERY OF THE HEMATOPOIETIC SYSTEM BY PRETREATMENT WITH VINCRISTINE
    JOHNKE, RM
    EVANS, MJ
    POGROW, RM
    EMMA, DA
    KOVACS, CJ
    RADIATION RESEARCH, 1983, 94 (03) : 651 - 651
  • [9] POST-IRRADIATION AVOIDANCE AND RECOVERY OF PREFERENCE OF SACCHARIN SODIUM IN MICE
    MOOS, WS
    LEVAN, H
    KLAUSER, R
    MEDICINA EXPERIMENTALIS, 1968, 18 (01): : 45 - &
  • [10] THE SUSCEPTIBILITY OF IRRADIATED MICE TO INFECTION AS A FUNCTION OF POST-IRRADIATION TIME
    SHECHMEISTER, IL
    BOND, VP
    SWIFT, MN
    JOURNAL OF IMMUNOLOGY, 1952, 68 (01): : 87 - 95