Peripheral and synovial mechanisms of humoral autoimmunity in rheumatoid arthritis

被引：6

作者：

Corsiero, Elisa ^{[1
]}

Pitzalis, Costantino ^{[1
]}

Bombardieri, Michele ^{[1
]}

机构：

[1] Queen Mary Univ London, Barts & London Sch Med & Dent, John Vane Sci Ctr, Ctr Expt Med & Rheumatol,William Harvey Res Inst, London EC1M 6BQ, England

来源：

DRUG DISCOVERY TODAY | 2014年 / 19卷 / 08期

基金：

英国医学研究理事会;

关键词：

B-CELL SUBPOPULATIONS; CLASS SWITCH RECOMBINATION; PLASMA-CELLS; LYMPHOID NEOGENESIS; SALIVARY-GLANDS; BLOOD; EXPRESSION; ACCUMULATION; FIBROBLASTS; EXCLUSION;

D O I：

10.1016/j.drudis.2014.05.017

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

One of the hallmarks of rheumatoid arthritis (RA) is the development of humoral autoimmunity resulting in circulating autoantibodies. The clinical efficacy of B cell-depleting biologic treatments highlighted a key role for autoreactive B cell activation in the pathogenesis of RA. In this review, we discuss the key mechanisms leading to breach of B cell self-tolerance in the peripheral compartment. We also highlight the contribution of synovial ectopic lymphoid structures (ELS) in the development of functional niches of autoreactive B cells promoting humoral autoimmunity in the inflamed RA joints over and above secondary lymphoid organs (SLO).

引用

页码：1161 / 1165

页数：5

共 50 条

[1] HUMORAL AUTOIMMUNITY TO CARTILAGE IN RHEUMATOID-ARTHRITIS
ENZMANN, H
MOLLENHAUER, J
BRUNE, K
AGENTS AND ACTIONS, 1990, 29 (1-2): : 114 - 116
[2] Synovial intracellular citrullinated proteins are pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunity in vivo.
De Rycke, L
Cantaert, T
Nicholas, AP
Kruithof, E
Vandekerckhove, B
Veys, EM
De Keyser, F
Baeten, D
ARTHRITIS AND RHEUMATISM, 2004, 50 (09): : S525 - S526
[3] Type I interferons have no major influence on humoral autoimmunity in rheumatoid arthritis
Cantaert, Tineke
van Baarsen, Lisa G.
Wijbrandts, Carla A.
Thurlings, Rogier M.
van de Sande, Marleen G.
Bos, Carina
van der Pouw, Tineke Kraan
Verweij, Cor L.
Tak, Paul P.
Baeten, Dominique L.
RHEUMATOLOGY, 2010, 49 (01) : 156 - 166
[4] Systemic humoral autoimmunity but joint-specific inflammation: The syndrome of rheumatoid arthritis
Wu, Xiaobo
Shih, Fei
Atkinson, John P.
ARTHRITIS AND RHEUMATISM, 2007, 56 (09): : 2823 - 2828
[5] AUTOIMMUNITY AND RHEUMATOID ARTHRITIS
THOMPSON, RA
BRITISH MEDICAL JOURNAL, 1965, 2 (5457): : 360 - &
[6] MOLECULAR MECHANISMS LINKING GENETIC VARIANTS TO THE INVASIVENESS OF RHEUMATOID ARTHRITIS SYNOVIAL FIBROBLASTS IN RHEUMATOID ARTHRITIS
Flanagan, E.
Dorris, E.
Peltea, A.
Linehan, E.
Creevey, K.
Galligan, M.
Fearon, U.
Veale, D.
Wilson, G.
IRISH JOURNAL OF MEDICAL SCIENCE, 2015, 184 : 551 - 551
[7] AUTOIMMUNITY AND RHEUMATOID ARTHRITIS
SHATIN, R
BRITISH MEDICAL JOURNAL, 1965, 2 (5468): : 1002 - &
[8] Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase are pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunity
De Rycke, L
Nicholas, AR
Cantaert, T
Kruithof, E
Echols, JD
Vandekerckhove, B
Veys, EM
De Keyser, F
Baeten, D
ANNALS OF THE RHEUMATIC DISEASES, 2005, 64 : 163 - 163
[9] Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase as pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunity
De Rycke, L
Nicholas, AP
Cantaert, T
Kruithof, E
Echols, JD
Vandekerckhove, B
Veys, EM
De Keyser, F
Baeten, D
ARTHRITIS AND RHEUMATISM, 2005, 52 (08): : 2323 - 2330
[10] METABOLIC AND SECRETORY PROPERTIES OF PERIPHERAL AND SYNOVIAL GRANULOCYTES IN RHEUMATOID-ARTHRITIS
VANDESTADT, RJ
VANDEVOORDEVISSERS, E
FELTKAMPVROOM, TM
ARTHRITIS AND RHEUMATISM, 1980, 23 (01): : 17 - 23

← 1 2 3 4 5 →