The role of RXR-α in retinoic acid-induced cleft palate as assessed with the RXR-α knockout mouse

被引：0
|
作者：
Nugent, P
Sucov, HM
Pisano, MM
Greene, RM
机构：
[1] Univ Louisville, Sch Dent, Dept Mol Cellular & Craniofacial Biol, Louisville, KY 40292 USA
[2] Univ Louisville, Birth Defects Ctr, Louisville, KY 40292 USA
[3] Univ So Calif, Sch Med, Dept Cell & Neurobiol, Inst Med Genet, Los Angeles, CA USA
来源：
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY | 1999年 / 43卷 / 06期
关键词：
RXR-alpha; retinoic acid; cleft palate;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Treatment of pregnant mice with retinoic acid (RA) in mid-gestation produces cleft palate and limb defects in the fetuses. RXR-alpha has been previously shown to mediate the teratogenic effects of RA in the limb. In this study, we show that RXR-alpha is also involved in retinoid-induced palatal clefting. Treatment of RXR-alpha knockout mice with a teratogenic dose of RA on gestation day 11 or 12 induces cleft palate at a lower frequency than that seen in wild-type animals.
引用
收藏
页码：567 / 570
页数：4
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