SYNTHESIS, CHARACTERIZATION AND DNA INTERACTION OF NOVEL PLATINUM(II) COMPLEXES CONTAINING SUBSTITUTED BENZIMIDAZOLE LIGANDS

Eight novel Pt(II) complexes corresponding to the following general formula [PtCl2(L-1-L-4)(2)] (C1 -C4) and [PtI2((L1-L4))(2)] (C5-C8) in which 5(6)-chloro/or-methyl-2-H/or-methylbenzimidazole (L-1-L-4) played the key role as carrier ligands were synthesized and characterized by elemental analysis, IR and H-1 NMR. Considering leaving group functions, the anionic ligand iodido and chloro were utilized with the purpose of studying the interaction between the synthesized complexes and pBR322 plasmid DNA by using cisplatin as positive control throughout the Agarose Gel Electrophoresis method. Therefore, looking after plasmid DNA interacting outcomes, synthesized complexes modified the tertiary structure of pBR322 plasmid DNA, and the results showed that the complex C2 ([PtCl2(L-2)(2)]) was highly active compound regarding to all synthesized complexes.