Antibody against TDP-43 phosphorylated at serine 369 suggests conformational differences of TDP-43 aggregates among FTLD-TDP subtypes (vol 140, pg 645, 2020)

被引:9
|
作者
Neumann, Manuela [1 ,2 ]
Frick, Petra [1 ]
Paron, Francesca [3 ]
Kosten, Jonas [1 ]
Buratti, Emanuele [3 ]
Mackenzie, Ian R. [4 ,5 ]
机构
[1] German Ctr Neurodegenerat Dis DZNE Tubingen, Mol Neuropathol Neurodegenerat Dis, Otfried Mullerstr 23, D-72072 Tubingen, Germany
[2] Univ Hosp Tubingen, Dept Neuropathol, Tubingen, Germany
[3] Int Ctr Genet Engn & Biotechnol ICGEB, Dept Mol Pathol, Trieste, Italy
[4] Univ British Columbia, Dept Pathol, Vancouver, BC, Canada
[5] Vancouver Gen Hosp, Vancouver, BC, Canada
关键词
D O I
10.1007/s00401-020-02242-7
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Due to a mistake with incorrect assignment of the originally planned amino acid residues 368-379 to the protein sequence of TDP-43 for antibody production by the contracted company, a peptide corresponding to amino acids 362-373 with a phosphorylated serin at 369 instead of a peptide corresponding to amino acids 368-379 with a phosphorylated serin at 375 was synthesized and used for antibody generation and purification.
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收藏
页码:137 / 137
页数:1
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